Epidemiological Practices in Research on Small Effects

  • Hans Hoffmeister
  • Moyses Szklo
  • Michael Thamm
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-viii
  2. Moyses Szklo
    Pages 5-6
  3. Ernest L. Wynder
    Pages 7-16
  4. Genevieve Matanoski
    Pages 45-54
  5. Hans Hoffmeister
    Pages 59-69
  6. Lenore Kohlmeier
    Pages 93-97
  7. Steven Goodman
    Pages 113-118
  8. Colin Begg
    Pages 119-120
  9. Kay Dickersin
    Pages 121-126
  10. Richard Doll
    Pages 127-132

About these proceedings


In modern societies, epidemiology is increasingly confronted with the detection and evaluation of small risks, especially from environmental exposures and various lifestyles. The question arises, if for example, the risks from residential magnetic field exposure and childhood leukaemia, or dietry fat intake and breast cancer are real, or if they can safely be considered as artefacts, as a consequence of methodological limits of epidemiology? More and more conflicting results are produced and are putting the general public in a state of uncertainty, which, if public pressure is strong enough, might result in political action without the required sound scientific justification. Therefore, strategies have to be developed, to minimise the "noise" in epidemiological studies, in order to get a clearer picture of the real influencing factors, and to reduce the chance of false results. Based on an international conference on this topic, attended by some of the world's leading epidemiologists, this book is presenting an overview of the main difficulties researchers might encounter when studying small risks. It is also offering recommendations on how to proceed when small risks are under study in order to avoid spurious results.


Radiologieinformationssystem case-control cohort studies epidemiological epidemiology

Editors and affiliations

  • Hans Hoffmeister
    • 1
  • Moyses Szklo
    • 2
  • Michael Thamm
    • 1
  1. 1.Robert Koch-InstitutBerlinGermany
  2. 2.School of Hygiene and Public Health, Department of EpidemiologyJohns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80465-6
  • Online ISBN 978-3-642-80463-2
  • Buy this book on publisher's site