RNP Particles, Splicing and Autoimmune Diseases

  • Johannes Schenkel

Part of the Springer Lab Manual book series (SLM)

Table of contents

  1. Front Matter
    Pages I-X
  2. Frank Jung, Constantin E. Sekeris, Johannes Schenkel
    Pages 1-28
  3. Ulf Skoglund, Lars-Göran Öfverstedt, Bertil Daneholt
    Pages 72-94
  4. Panayiotis G. Vlachoyiannopoulos
    Pages 141-154
  5. Martin Blüthner
    Pages 155-183
  6. Johannes Schenkel, Frank Jung, Apostolia Guialis, Angela Krämer
    Pages 184-210
  7. Back Matter
    Pages 211-225

About this book


The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles.
Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.


Autoimmunkrankheit RNA RNP particles (ribonucleoprotein particles) Zellkern autoantibodies autoantigens electron microscopy m-RNA splicing

Editors and affiliations

  • Johannes Schenkel
    • 1
  1. 1.II. Physiologisches InstitutUniversität HeidelbergHeidelbergGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-48975-4
  • Online ISBN 978-3-642-80356-7
  • Buy this book on publisher's site