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Pathology of Septic Shock

  • E. T. Rietschel
  • Hermann Wagner

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 216)

Table of contents

  1. Front Matter
    Pages I-IX
  2. E. T. Rietschel, H. Brade, O. Holst, L. Brade, S. Müller-Loennies, U. Mamat et al.
    Pages 39-81
  3. S. Bhakdi, I. Walev, D. Jonas, M. Palmer, U. Weller, N. Suttorp et al.
    Pages 101-118
  4. D. Pajkrt, S. J. H. van Deventer
    Pages 119-132
  5. T. J. Evans, J. Cohen
    Pages 189-207
  6. L. G. Thus, A. B. J. Groeneveld, C. E. Hack
    Pages 209-237
  7. Back Matter
    Pages 313-324

About this book

Introduction

Severe sepsis and septic shock are the most serious compli­ cations of bacterial infections. Both gram-positive and gram­ negative bacteria can trigger these extreme inflammatory re­ sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem­ istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan­ isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.

Keywords

Activation Antigen Endotoxin Lipopolysaccaride Signal pathways bacteria cytokine immune system immunosuppression influence molecular mechanisms pathology sepsis shock toxin

Editors and affiliations

  • E. T. Rietschel
    • 1
  • Hermann Wagner
    • 2
  1. 1.Forschungszentrum BorstelZentrum für Medizin und BiowissenschaftenBorstelGermany
  2. 2.Institut für Medizinische Mikrobiologie, Immunologie und HygieneTechnische Universität MünchenMünchenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80186-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80188-4
  • Online ISBN 978-3-642-80186-0
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site