Apolipoprotein E and Alzheimer’s Disease

  • A. D. Roses
  • K. Weisgraber
  • Y. Christen
Conference proceedings

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XX
  2. A. D. Roses, W. J. Strittmatter, A. M. Saunders, D. E. Schmechel, M. A. Pericak-Vance
    Pages 1-10
  3. J. Poirier, M.-C. Delisle, R. Quirion, I. Aubert, J. Rocheford, I. Rousse et al.
    Pages 20-28
  4. D. E. Schmechel, M. O. Tiller, P. Tong, M. McSwain, S.-H. Han, R. Ange et al.
    Pages 29-48
  5. E. Masliah, M. Mallory, M. Alford, I. Veinbergs, A. D. Roses
    Pages 59-73
  6. K. Ikeda, T. Aizawa, S. Haga, N. Otsuka, M. Mizuguchi, Y. Namba et al.
    Pages 74-96
  7. B. T. Hyman, G. W. Rebeck, R. Christie, K. Page, M. Irizarry, D. K. Strickland
    Pages 97-102
  8. E. Mandelkow, O. Schweers, J. Biernat, B. Trinczek, G. Drewes, E.-M. Mandelkow
    Pages 126-135
  9. W. J. Strittmatter, V. de Serrano, D. Y. Huang, M. E. Martin, A. D. Roses, A. M. Saunders
    Pages 145-150
  10. B. Frangione, E. M. Castaño, F. Prelli, C. Soto, J. Ghiso, T. Wisniewski
    Pages 151-160
  11. B. Leininger-Muller, C. Jolivalt, T. Pillot, P. Lagrange, M. H. Livertoux, M. C. Grassiot et al.
    Pages 161-169
  12. G. Maestre, P. Schofield, M. Chun, M.-X. Tang, B. Tycko, R. Mayeux
    Pages 170-179
  13. M. A. Pericak-Vance, P. M. Conneally, G. W. Small, A. M. Saunders, L. Yamaoka, P. C. Gaskell et al.
    Pages 180-186
  14. Back Matter
    Pages 187-188

About these proceedings


There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.


Alzheimer's disease Alzheimer´s disease Brain aging biochemistry brain central nervous system lipoprotein nervous system neuropathology

Editors and affiliations

  • A. D. Roses
    • 1
  • K. Weisgraber
    • 2
  • Y. Christen
    • 3
  1. 1.Joseph and Kathleen Bryan Alzheimer’s Disease Research Center Departments of Medicine (Neurology) and NeurobiologyDuke University Medical CenterDurhamUSA
  2. 2.Gladstone Institute of Cardiovascular Disease Department of Pathology, Cardiovascular Research InstituteUniversity of CaliforniaSan FranciscoUSA
  3. 3.Fondation IPSENParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80111-2
  • Online ISBN 978-3-642-80109-9
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site