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New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

  • Ernst-D. Kreuser
  • P. M. Schlag

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 142)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Basic Research

    1. E. R. Greenberg
      Pages 9-18
    2. M. Streit, R. Schmidt, R. U. Hilgenfeld, E. Thiel, E. D. Kreuser
      Pages 19-50
    3. K. Moelling, B. Strack, G. Radziwill
      Pages 63-71
  3. Diagnostic Tools

  4. Therapeutic Approaches

    1. P. Goldin-Lang, E.-D. Kreuser, H. J. F. Zunft
      Pages 163-192
    2. S. Faiss, H. Scherübl, E. O. Riecken, B. Wiedenmann
      Pages 193-207
    3. B. Rau, M. Hünerbein, B. Reingruber, P. Hohenberger, P. M. Schlag
      Pages 209-215
    4. H. Wilke, H. J. Meyer, U. Fink
      Pages 237-248
    5. V. Budach, L. Schlenger, P. Feyer
      Pages 257-279
    6. P. Wust, J. Gellermann, B. Rau, J. Löffel, A. Speidel, H. Stahl et al.
      Pages 281-309
    7. R. U. Hilgenfeld, M. Streit, E. Thiel, E.-D. Kreuser
      Pages 353-380
    8. E. Holz, R. Raab, G. Riethmüller
      Pages 381-400
    9. H. Keck, J. M. Langrehr, V. Henneken, M. Knoop, P. Neuhaus
      Pages 401-413
    10. H. Riess, P. Htun, J. Löffel, D. Huhn
      Pages 415-424
  5. Back Matter
    Pages 431-439

About these proceedings

Introduction

This volume focuses on new and exciting approaches in the molecular and clinical management of gastrointestinal tumors. The first part presents recent insights into carcinogenesis, including alterations in cyclins and adhesion receptors, molecular structures which might be new targets of gene therapy. The second part of the volume offers new diagnostic tools, such as receptors for gastrointestinal hormones, proliferation markers, tumor suppressor proteins, and the multiple drug resistance gene, predicting response to therapy and prognosis in gastrointestinal tumors. The third part gives an update of successful approaches in primary and secondary prevention of colorectal carcinoma. Nutritional factors and pharmacologic agents can clearly decrease the risk, and fecal occult blood tests and endoscopy can reduce the mortality in colorectal carcinoma. Laparoscopic staging with subsequent biopsy of suspicious lymph nodes provides essential information in esophageal and gastric cancer. In locally advanced gastric cancer, preoperative chemotherapy provides sufficient evidence to investigate this approach as compared to primary surgery. Standards have recently been established in the adjuvant treatment of patients with gastrointestinal carcinoma, and promising new drugs, including monoclonal antibodies, thymidylate synthase, and topoisomerase inhibitors, as well as taxoids, are currently being tested in phase I, II, and III trials of gastrointestinal tumors.

Keywords

Tumor cancer carcinogenesis carcinoma chemotherapy classification gene therapy hormones immunotherapy lymphoma molecular biology neuroendocrine tumor prevention radiation therapy radiotherapy

Editors and affiliations

  • Ernst-D. Kreuser
    • 1
  • P. M. Schlag
    • 2
  1. 1.Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und OnkologieFreie Universität BerlinGermany
  2. 2.Robert-Rössle Klinik am Max-Delbrück-CentrumHumboldt-UniversitätGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80035-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80037-5
  • Online ISBN 978-3-642-80035-1
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site