The Endothelium in Cardiovascular Disease

Pathophysiology, Clinical Presentation and Pharmacotherapy

  • Thomas F. Lüscher

Table of contents

  1. Front Matter
    Pages I-XI
  2. A. L. Clavell, J. C. Burnett Jr.
    Pages 33-42
  3. T. J. Rabelink, P. Morrison
    Pages 84-96
  4. A. Fernandez-Cruz, R. Patiño, J. Ibarra, L. Fernandez, M. Roldan, J. Moya et al.
    Pages 157-170
  5. D. J. Stewart, D. Langleben
    Pages 184-194
  6. Back Matter
    Pages 195-197

About this book


The endothelium is an important regulator of the cardiovascular system by releasing nitric oxide, prostacyclin, endothelin-1, and other endothelium-derived constricting factors which are able to profoundly affect vascular tone and the function of circulating blood cells such as platelets and monocytes. In addition, the endothelium is a source of factors which can activate or inhibit vascular smooth muscle cell migration and proliferation. Endothelial dysfunction, with an imbalanced production of these factors, therefore, can profoundly affect vascular tone and structure as well as the function of circulating blood cells. Endothelial dysfunction has been demonstrated in various forms of cardiovascular diseasae. Cardiovascular drugs already in clinical use or in development are able to interfere with certain aspects of endothelial function and may be useful in protecting the vessels and, hence, in preventing the development of cardiovascular disease.


atherosclerosis cardiovascular cardiovascular disease endothelium heart heart disease hypertension pathophysiology physiology vascular disease

Editors and affiliations

  • Thomas F. Lüscher
    • 1
  1. 1.Abteilung KardiologieInselspitalBernSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79805-4
  • Online ISBN 978-3-642-79803-0
  • Buy this book on publisher's site