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Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health

  • Emel Arinç
  • John B. Schenkman
  • Ernest Hodgson
Conference proceedings

Part of the NATO ASI Series book series (volume 90)

Table of contents

  1. Front Matter
    Pages I-IX
  2. John B. Schenkman, Ingela Jansson
    Pages 1-19
  3. John B. Schenkman, Andrei I. Voznesensky
    Pages 47-63
  4. Yoshiaki Fujii-Kuriyama, Osamu Gotoh
    Pages 65-85
  5. Eric F. Johnson, Colin N. A. Palmer, Mei-H. Hsu, Keith J. Griffin
    Pages 87-103
  6. Toby H. Richardson, Mei-H. Hsu, Eric F. Johnson
    Pages 105-134
  7. Richard M. Philpot, Emmanuel Atta-Asafo-Adjei, Kave Nikbakht, Vicki Burnett, Michael P. Lawton
    Pages 209-224
  8. Ernest Hodgson, Bonnie L. Blake, Patricia E. Levi, Richard B. Mailman, Michael P. Lawton, Richard M. Philpot et al.
    Pages 225-235
  9. Chung S. Yang, Theresa J. Smith
    Pages 249-259
  10. Diana Anderson
    Pages 303-396
  11. F. Oesch, H. J. Arens, F. Fähndrich, T. Friedberg, B. Richter, H. Yamazaki et al.
    Pages 411-427
  12. Ernest Hodgson, Randy L. Rose, Nancy H. Adams, Nora J. Deamer, Mary Beth Genter, Krishnappa Venkatesh et al.
    Pages 461-478
  13. Anthony Y. H. Lu
    Pages 503-513
  14. Sergey V. Kotelevtsev, Victor V. Obrazsov, Cyril N. Novicov, Ludmila I. Stepanova
    Pages 533-548
  15. Back Matter
    Pages 605-620

About these proceedings

Introduction

Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

Keywords

Oxidation biology carcinogenesis cell cell culture cytochrome P450 drug enzyme enzymes metabolism molecular biology mutagen toxicity toxicology translation

Editors and affiliations

  • Emel Arinç
    • 1
  • John B. Schenkman
    • 2
  • Ernest Hodgson
    • 3
  1. 1.Department of BiologyMiddle East Technical UniversityAnkaraTurkey
  2. 2.Department of ToxicologyUniversity of Connecticut Health CenterFarmingtonUSA
  3. 3.Department of ToxicologyNorth Carolina State UniversityRaleighUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79528-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79530-5
  • Online ISBN 978-3-642-79528-2
  • Buy this book on publisher's site