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Absorption of Orally Administered Enzymes

  • Conference proceedings
  • © 1995

Overview

Authors:
  1. Michael L. G. Gardner

    1. Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, UK

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  2. Klaus-Jürgen Steffens

    1. Pharmazeutisches Institut Pharmazeutische Technologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany

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Table of contents (10 papers)

  1. Front Matter

    Pages I-X
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  2. A Review of Current Knowledge of Gastrointestinal Absorption of Intact Proteins Including Medicinal Preparations of Proteolytic Enzymes

    • M. L. G. Gardner
    Pages 1-7

  3. Persorption — Criticism and Agreement as Based upon In Vitro and In Vivo Studies on Mammals

    • K.-J. Steffens
    Pages 9-21

  4. Modes of Absorption of Macromolecular Substances

    • G. Gebert
    Pages 23-28

  5. The Quantitative Absorption of Orally Administered Proteins and Histological Evidence of Enzymes in the Wound

    • J. Seifert, D. Siebrecht, J.-P. Lange, G. Axt, F. B. Bambas
    Pages 29-38

  6. Oral Route of Peptide and Protein Drug Delivery

    • V. H. L. Lee
    Pages 39-46

  7. Intestinal Absorption of Undegraded Bromelain in Humans

    • J. V. Castell
    Pages 47-60

  8. Investigations on the Effect of Protease Mixtures on Vessels

    • G. Bundschuh
    Pages 61-68

  9. Parameters of Serological Effects Following Oral Administration of Mulsal N: Results of a Double-Blind Study

    • R. Kunze
    Pages 69-75

  10. Enzyme Influences on Adhesion Molecules and Their Clinical Implications

    • G. P. Tilz, V. Demel
    Pages 77-81

  11. Bioavailability of Therapeutically Used Hydrolytic Enzymes

    • P. Streichhan, W. van Schaik, G. Stauder
    Pages 83-94

  12. Back Matter

    Pages 95-97
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Keywords

About this book

A large number of clinical studies have already been conducted in which animal serine and vegetable cysteine proteinases and combination preparations of them for oral use have been shown to arrest and heal acute and chronic inflammation. The pharmacodynamics and pharmacokinetics of these preparations are still a matter of controversy, however, because it is difficult to determine the absorption of these active substances. Experiments have produced false-positive and false-negative results no matter which procedure is used. The heterogeneity of knowledge within this field prompted a symposium, held in 1993 in Munich. This volume contains the findings of this meeting and does away with old dogmas - enzymes can indeed be absorbed!

Authors and Affiliations

  • Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, UK

    Michael L. G. Gardner

  • Pharmazeutisches Institut Pharmazeutische Technologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany

    Klaus-Jürgen Steffens

Bibliographic Information

  • Book Title: Absorption of Orally Administered Enzymes

  • Authors: Michael L. G. Gardner, Klaus-Jürgen Steffens

  • DOI: https://doi.org/10.1007/978-3-642-79511-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-642-79513-8Due: 25 December 2011

  • eBook ISBN: 978-3-642-79511-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 97

  • Topics: Pharmacology/Toxicology, Hepatology, Gastroenterology, Allergology, Immunology

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