The Cytoskeleton

  • B. M. Jockusch
  • E. Mandelkow
  • K. Weber

Table of contents

  1. Front Matter
    Pages I-IX
  2. J. R. McIntosh, V. A. Lombillo, C. Nislow, E. A. Vaisberg
    Pages 1-9
  3. M. Bernstein, P. L. Beech, K. A. Johnson, K. G. Kozminski, J. L. Rosenbaum
    Pages 11-21
  4. K. C. Holmes
    Pages 29-39
  5. B. M. Jockusch, M. Kroemker, K. Schlüter
    Pages 49-60
  6. N. Pante, R. Bastos, I. McMorrow, K. N. Goldie, B. Burke, U. Aebi
    Pages 89-92
  7. A. A. Noegel, B. Köppel, U. Gottwald, W. Witke, R. Albrecht, M. Schleicher
    Pages 117-126
  8. J. M. Sanger, J. W. Sanger
    Pages 127-134
  9. E. Mandelkow, J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke et al.
    Pages 143-160

About these proceedings


This volume contains the proceedings of the 45th Mosbach Colloquium of the German Society for Biological Chemistry (GBCh). The 1994 meeting was the first in this series devoted to the cytoskeleton. This complex system enables the eukaryotic cell to form discrete contacts with neighboring cells and the extracellular matrix, to differentiate, to move, change shape, transport organelles, and proliferate. These diverse tasks are performed by three distinct fibrillar networks: microfilaments, microtubules, and intermediate filaments, which are composed of structural and regulatory elements. The precise interplay between the components in time and space determines which of the various functions is performed. The rapid progress made in this field is best exemplified by the recent unraveling of the molecular mechanism of intracellular movement. Here, the modem microscopies of today allow the motility to be visualized in realtime. Molecular biology has dissected the functional domains of the motor proteins involved and provided material required for biochemical studies as well as structure analysis by X-ray diffraction and NMR. Thus, it is now possible to integrate cellular behavior and molecular structure in a unifying picture. Other recent advances in the field point to the role of cytoskeletol proteins in human diseases, from allergies to skin blistering, atrophies, and Alzheimers's disease. The book is an up-to-date account of the field told by an international set of experts, a broad introduction to newcomers, and a valuable reference for practitioners. January 1995 Brigitte M.


Alzheimer's disease DNA Organelle Zytoskelett cell chromosome cytoskeleton evolution membrane microscopy protein protein structure proteins regulation translation

Editors and affiliations

  • B. M. Jockusch
    • 1
  • E. Mandelkow
    • 2
  • K. Weber
    • 3
  1. 1.Zoologisches Institut Abteilung ZellbiologieTechnische Universität BraunschweigBraunschweigGermany
  2. 2.AG für strukturelle MolekularbiologieMax-Planck-GesellschaftGermany
  3. 3.Max-Plank-Institut für Biophysikalische ChemieGöttingenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79484-1
  • Online ISBN 978-3-642-79482-7
  • Series Print ISSN 0366-5887
  • Buy this book on publisher's site