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Apoptosis in Immunology

  • Guido Kroemer
  • Carlos Martinez-A.

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 200)

Table of contents

  1. Front Matter
    Pages I-XI
  2. P. Sarthou, L. Benhamou, P.-A. Cazenave
    Pages 15-37
  3. L. Bosca, C. Stauber, S. Hortelano, E. Baixeras, C. Martinez-A.
    Pages 39-50
  4. J. W. Montague, J. A. Cidlowski
    Pages 51-65
  5. M. Jondal, Y. Xue, D. J. McConkey, S. Okret
    Pages 67-79
  6. D. J. McConkey, S. Orrenius
    Pages 95-105
  7. L. H. Boise, A. R. Gottschalk, J. Quintáns, C. B. Thompson
    Pages 107-121
  8. D. J. Harrison, S. E. M. Howie, A. H. Wyllie
    Pages 123-135
  9. J. Woronicz, B. Calnan, A. Winoto
    Pages 137-146
  10. S. W. Smith, K. A. McLaughlin, B. A. Osborne
    Pages 147-162
  11. J. C. Ameisen, J. Estaquier, T. Idziorek, F. De Bels
    Pages 195-211
  12. Back Matter
    Pages 237-244

About this book

Introduction

In any movement of their life, immune cells, especially T and B lymphocytes, are confronted with an essential choice: to continue their existence or to commit a sort of metabolic suicide that is referred to as apoptosis or programmed cell death. In contrast to most philosophers, lymphocytes and their precursors are constantly susceptible to suicide, and it even appears that the usual cause of T or B cell elimination is suicide rather than death from natural causes, accidents or murder. This book provides a vast overview of lymphocytes suicide: external triggers and internal motives leading to suicidal impulses, accomplices in self-destruction, weapons implicated in self-execution, removal of dead bodies and pharmacological prevention of suicide. Most of the chapters in this book are devoted to the physiology of apoptosis. The goal is to unmask the external triggers of apoptosis, unravel the signal transduction pro­ cesses involved therein and describe the role of oncogenes, "death genes" and effector molecules in the apoptotic cas­ cade. The remaining chapters deal with the pathophysiologi­ cal aspects of lymphocyte apoptosis, namely, as a host contribution to HIV-induced lymphopenia, and therapeutic strategies for the avoidance of lymphocyte death. We are confident that this compendium will contribute to the exploration of cellular suicide, not only from a basic scientist's viewpoint but also with regard to the possible clinical implications of apoptosis (dys)regulation. Far from having a depressing effect on the reader, cellular suicide may thus provide a source of both intellectual excitement and therapeutic inspiration.

Keywords

AIDS Signal Viren Zelltod apoptosis biology cell immunology lymphocytes molecular biology oncogenes onkogene Viren programmed cell death regulation signal transduction

Editors and affiliations

  • Guido Kroemer
    • 1
  • Carlos Martinez-A.
    • 2
  1. 1.Génétique Moléculaire et Biologie du DéveloppmentCNRS-UPR 420Villejuif CedexFrance
  2. 2.Centro Nacional de Biotecnologia CSIC Campus de CantoblancoUniversidad AutonomaMadridSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79437-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79439-1
  • Online ISBN 978-3-642-79437-7
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site