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Use of Mechanistic Information in Risk Assessment

Proceedings of the 1993 EUROTOX Congress Meeting Held in Uppsala, Sweden, June 30–July 3, 1993

  • Hermann M. Bolt
  • Björn Hellman
  • Lennart Dencker

Part of the Archives of Toxicology, Supplement 16 book series (TOXICOLOGY, volume 16)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Baltic Sea Pollution

  3. Contact and Respiratory Sensitisation

    1. Front Matter
      Pages 61-61
    2. Rik J. Scheper, B. Mary, E. von Blomberg
      Pages 63-70
    3. Th. Maurer, A. Arthur, Ph. Bentley
      Pages 71-76
    4. Jürgen Pauluhn
      Pages 77-86
    5. G. Frank Gerberick
      Pages 95-101
  4. Developmental Toxicity

  5. Role of Mechanistic Studies of Toxicity in Risk Assessment

  6. Mechanisms of Metal Toxicity

    1. Front Matter
      Pages 183-183
    2. Ph. Druet
      Pages 185-191
    3. D. Beyersmann, A. Hartwig
      Pages 192-198
  7. Toxicokinetics of Drugs

    1. Front Matter
      Pages 199-199
    2. Henrik E. Poulsen, Steffen Loft
      Pages 211-222
    3. Per Hartvig, Joakim Tedroff, Anders Lilja, Karl Johan Lindner, Bengt Långström
      Pages 223-232
    4. Robert M. J. Ings
      Pages 233-241
  8. Mechanisms of Carcinogenicity and Risk Assessment

    1. Front Matter
      Pages 251-251
    2. Ken Brown, Chris Kemp, Phil Burns, Allan Balmain
      Pages 253-260
    3. G. M. Ledda-Columbano, P. Coni, A. Columbano
      Pages 271-280
  9. Late Manuscripts

    1. Front Matter
      Pages 295-295
  10. Young Scientists Poster Award

  11. Back Matter
    Pages 311-312

About these proceedings

Introduction

M. Pliftski Institute of Oceanography, GdaJisk University 46 Pilsudskiego Av. 81-378 Gdynia, Poland 2 The Baltic Sea with 366,000 km is only 0. 1% of the world's oceans but nevertheless, unique in many ways. The Baltic Sea is the largest area of brackish water in the world. As a formation of nature, it is a sea that in many ways resembles a lake. This makes its flora and fauna interesting and well adapted to the brackish water environment. The recent stage of biocoenosis composition is influenced by several features. Historically, during the last glaciation, when the Baltic was sometimes a huge marine bay and sometimes a large, freshwater lake, several ecosystems developed and were successively replaced. The flora and fauna composition of those previous biocoenosis was discovered from the geological layers corresponding to the Yoldic Sea, the Ancylus Lake and the Littorina Sea periods. Recently the marine influence has come from the North Sea water inflow, which greatly affects the salinity of the deep water. The freshwater influence comes from the fluvial water which gives the surface layer a lower salinity value. Salinity in the Baltic regions varies greatly - Gulf of Bothnia 2-4%0, the central Baltic proper 7-13%0, the Kattegat 15-300/00 in the surface water and 32- 34%0 in the bottom water, the Skagerrak 20-300/00 in the surface and 32-35%0 in the bottom water.

Keywords

Pharmakologie Umweltschutz ecotoxicology environment environmental protection gene expression kinetics perception pharmacokinetics pharmacology prevention receptor research toxicity toxicology

Editors and affiliations

  • Hermann M. Bolt
    • 1
  • Björn Hellman
    • 2
  • Lennart Dencker
    • 3
  1. 1.Institut für Arbeitsphysiologie an der Universität DortmundDortmundGermany
  2. 2.Department of Occupational MedicineUppsala University HospitalUppsalaSweden
  3. 3.Department of Pharmaceutical Biosciences: Toxicology, BMCUppsala UniversityUppsalaSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78640-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78642-6
  • Online ISBN 978-3-642-78640-2
  • Series Print ISSN 0171-9750
  • Buy this book on publisher's site