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Dupuytren’s Disease

Pathobiochemistry and Clinical Management

  • Alfred Berger
  • Axel Delbrück
  • Peter Brenner
  • Rolf Hinzmann

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Morphology

    1. Front Matter
      Pages 1-1
    2. W. Mohr, D. Wessinghage
      Pages 3-15
    3. G. A. C. Murrell, M. J. O. Francis, C. R. Howlett
      Pages 24-33
  3. Pathobiochemistry of Fibrillar Component

    1. Front Matter
      Pages 35-35
    2. E. J. Menzel, J. Neumüller, A. Rietsch, H. Millesi
      Pages 49-61
    3. G. A. C. Murrell, M. J. O. Francis
      Pages 62-69
  4. Proteoglycans and Glycosaminoglycans

    1. Front Matter
      Pages 71-71
    2. E. Gurr, M. Borchert, W. Borchert, A. Delbrück
      Pages 73-84
    3. N. Gässler, P. Brenner, A. Berger, A. Delbrück
      Pages 94-98
  5. Pathobiochemistry of Cells in Dupuytren’s Contracture

  6. Extracellular Matrix Components and Macromolecular Interactions

  7. Fibromatoses

    1. Front Matter
      Pages 191-191
    2. W. Mohr, D. Wessinghage
      Pages 193-201
    3. S. Shoshan, I. Babayof, I. Peleg, F. Grinnell, N. Ron, S. Funk et al.
      Pages 213-221
    4. G. A. C. Murrell, M. J. O. Francis
      Pages 227-234
  8. Clinical Findings and Epidemiology of Dupuytren’s Disease

    1. Front Matter
      Pages 235-235
    2. P. Mailänder, P. Brenner, A. Berger
      Pages 237-243
    3. P. Brenner, P. Mailänder, A. Berger
      Pages 244-254
  9. Clinical Management of Dupuytren’s Disease

  10. Back Matter
    Pages 297-302

About these proceedings

Introduction

In this volume a distinguished group of internationally renowned clinicians and basic researchers discuss the present state of knowledge of the etiologyand pathogenesis of Dupuytren's contracture, a disease responsible for a considerable portion of disabilities within the working population allover the world. Although the riddle of how the contracture of the palmar fascia develops is still unsolved, the data on the pathobiochemistry and clinic of Dupuytren's Disease achieved in recent years has led to a better understanding of the biochemical and morphological processes underlying the deformation and malfunction of the afflicted tissues. Research in Dupuytren's Disease now enters the era of molecular medicine, which opens up new experimental means of studying the pathological changes which occur during the formation of the contracture on a molecular level. In particular, data are presented as to the role of specific biological macromolecules influencing the phenotype expression of the palmar fascia cells which are involved in autoimmune reactions and present both at the cell surface as well as in the extracellular matrix to regulate cell-to-cell and cell-to-matrix interactions. In vitro cell culture models to investigate fibro-cytic modulations are available and havebeen applied to study the effects of specific biological molecules on isolated cells from healthy palmar fascia and Dupuytren's contracture. Complementary evaluations of morphological, epidemiological, and clinical data contribute essentially to the present understanding of the etiology and pathogenesis of Dupuytren's Disease. This comprehensive and informative summary of the state of the art is completed by numerous references affixed to the individual contributions.

Keywords

Aetiology Cellular Biology Dupuytren's Disease Extrazelluläre Matrix Histopathologie Histopathology Immunhistochemie Immunochemistry biochemistry chemistry phenotype

Editors and affiliations

  • Alfred Berger
    • 1
  • Axel Delbrück
    • 2
  • Peter Brenner
    • 1
  • Rolf Hinzmann
    • 2
  1. 1.Klinik für Plastische, Hand- und WiederherstellungschirurgieKrankenhaus Oststadt, Medizinische Hochschule HannoverHannoverGermany
  2. 2.Institut für Klinische Chemie IIKrankenhaus Oststadt, Medizinische Hochschule HannoverHannoverGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78517-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-57239-8
  • Online ISBN 978-3-642-78517-7
  • Buy this book on publisher's site