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Ataxia-Telangiectasia

  • Richard A. Gatti
  • Robert B. Painter

Part of the NATO ASI Series book series (volume 77)

Table of contents

  1. Front Matter
    Pages I-XXIII
  2. Introduction

    1. Front Matter
      Pages XIX-XIX
  3. Isolation of A-T Gene(s)

    1. Front Matter
      Pages 5-5
    2. F. Cornélis, M. James, D. Cherif, T. Tokino, J. Davies, D. Girault et al.
      Pages 23-35
    3. Ethan Lange, Richard A. Gatti, Eric Sobel, Patrick Concannon, Kenneth Lange
      Pages 37-54
    4. M. Stephen Meyn, Jennifer M. Lu-Kuo, Laura B. K. Herzing
      Pages 55-64
    5. Yael Ziv, Tsafi Danieli, Galit Rotman, Adam Sartiel, Anat Bar-Shira, N. G. J. Jaspers et al.
      Pages 65-74
    6. M. Z. Zdzienicka, G. W. C. T. Verhaegh, W. Jongmans, N. G. J. Jaspers, M. Oshimura, M. R. James et al.
      Pages 87-97
  4. A-T Heterozygotes and Complementation

    1. Front Matter
      Pages 99-99
    2. D. Scott, L. A. Jones, S. A. G. Elyan, A. Spreadborough, R. Cowan, G. Ribiero
      Pages 101-116
    3. Richard Wooster, Douglas F. Easton, Deborah Ford, Jonathan Mangion, Bruce A. J. Ponder, Julian Peto et al.
      Pages 127-135
    4. Amos Norman, H. Rodney Withers
      Pages 137-140
  5. Defining the A-T Defect

  6. A-T Variants

    1. Front Matter
      Pages 181-181
    2. O. Sanal, A. I. Berkel, F. Ersoy, I. Tezcan, H. Topaloglu
      Pages 183-189
    3. L. Chessa, M. Fiorilli
      Pages 191-197
    4. O. Porras, O. Arguedas, M. Arata, M. Barrantes, L. González, E. Sáenz
      Pages 199-207
    5. A. M. R. Taylor, C. M. McConville, C. G. Woods, P. J. Byrd, D. Hernandez
      Pages 209-231
  7. Overviews

    1. Front Matter
      Pages 233-233
    2. Martin F. Lavin
      Pages 235-255
    3. Robert B. Painter
      Pages 257-268
    4. Susan L. Perlman
      Pages 269-277
  8. Back Matter
    Pages 279-288

About these proceedings

Introduction

Ataxia-telangiectasia or A-T is a fatal progressive neurological disease of children. The symptoms indicate disruptions in the development of such diverse body parts as cerebellum, thymus and chromosomes. The patients are unduly sensitive to ionizing radiation, immunodeficient, and a third of them develops cancer. All of this stems from defects of a single gene. Provided here is an up-to-date review of all important work in thefield. A wide spectrum of topics is covered, namely genetics, chromosome 11 mapping, radiobiology, complementation, heterozygote identification, clinical variants, biochemistry, and treatment of A-T.

Keywords

Ataxia-Telangiectasia Cancer Research Cerebellar Ataxia Chromosom Gendefekt Gene Defect Immunodeficiency Immunschwäche Krebsforschung Neuropathologie Radiosensitivity Strahlenempfindlichkeit genetics

Editors and affiliations

  • Richard A. Gatti
    • 1
  • Robert B. Painter
    • 2
  1. 1.Department of PathologyUniversity of California Los Angeles School of MedicineLos AngelesUSA
  2. 2.Laboratory of Radiobiology and Environmental HealthUniversity of California San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78278-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78280-0
  • Online ISBN 978-3-642-78278-7
  • Buy this book on publisher's site