The Human Yolk Sac and Yolk Sac Tumors

  • Francisco F. Nogales

Table of contents

  1. Front Matter
    Pages I-XVI
  2. B. F. King, A. C. Enders
    Pages 1-32
  3. A. C. Enders, B. F. King
    Pages 33-47
  4. G. Migliaccio, A. R. Migliaccio
    Pages 70-83
  5. H. Enzan
    Pages 84-108
  6. D. Buffe, C. Rimbaut, J. A. Gaillard
    Pages 109-125
  7. E. A. Reece, E. Pinter, F. Naftolin
    Pages 135-160
  8. E. Ferrazzi, S. Garbo
    Pages 161-173
  9. F. F. Nogales, E. Beltran, F. Gonzalez
    Pages 174-194
  10. I. Damjanov, A. Damjanov, U. M. Wewer
    Pages 195-215
  11. F. F. Nogales, E. Beltran, M. Pavcovich
    Pages 228-244
  12. A. Talerman
    Pages 262-284
  13. P. B. Clement, R. H. Young
    Pages 285-308
  14. F. H. Dexeus, S. Ogden, A. Cangir, J. Ro, C. J. Logothetis
    Pages 343-358
  15. Back Matter
    Pages 359-367

About this book


I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo­ genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re­ search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten­ tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi­ potent, and we focused on the preimplantation embryo for the histo­ genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car­ cinomas in general were a caricature of the process of renewal of their normal counterpart.


Dottersack Dottersacktumoren Therapie biochemistry biology birth histology histopathology imaging imaging techniques pathology pregnancy ultrasound yolk sac yolk sac tumors

Editors and affiliations

  • Francisco F. Nogales
    • 1
  1. 1.Head of DepartmentUniversity HospitalGranadaSpain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77854-4
  • Online ISBN 978-3-642-77852-0
  • Buy this book on publisher's site