Risk Assessment of Prenatally-Induced Adverse Health Effects

  • Diether Neubert
  • Robert J. Kavlock
  • Hans-Joachim Merker
  • Jane Klein

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Introduction

    1. Diether Neubert, Robert J. Kavlock
      Pages 1-23
  3. Basis for Testing in Reproductive Toxicity

    1. Front Matter
      Pages 25-25
    2. Jeanne M. Manson
      Pages 27-43
    3. Andrew C. Scallet, William Slikker Jr.
      Pages 63-77
    4. Ludwig Machemer, Ulrich Schmidt, Beate Holzum
      Pages 85-100
  4. Risk Assessment as Practiced in Various Countries

    1. Front Matter
      Pages 101-101
    2. Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 149-151
    3. Francisco J. R. Paumgartten, Eduardo E. Castilla, Roque Monteleone Neto, Helena L. L. Coelho, Sarah H. Costa
      Pages 163-179
    4. Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 191-194
  5. Dose-Response Relationships and Quantitative Risk Assessment

    1. Front Matter
      Pages 195-195
    2. Reinhard Meister
      Pages 211-226
    3. Thomas Platzek, Gerd Bochert, Reinhard Meister, Diether Neubert
      Pages 245-266
    4. Elisabeth Koch, Ibrahim Chahoud, Diether Neubert
      Pages 267-278
    5. Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 289-290
  6. Special Methods and Approaches

    1. Front Matter
      Pages 291-291
    2. Reinhard Neubert, Ana Cristina Nogueira, Hans Helge, Ralf Stahlmann, Diether Neubert
      Pages 313-346
    3. Diether Neubert, Stephan Klug, Georg Golor, Reinhard Neubert, Annegret Felies
      Pages 347-376
    4. Ralf Stahlmann, Ibrahim Chahoud, Hans-Joachim Merker, Diether Neubert
      Pages 397-417
    5. Gabriele M. Rune, Jutta Hartmann, Philippe De Souza
      Pages 419-431
    6. Jorge Cervós-Navarro, Gundula Hamdorf, Angela Becker, Andreas Scheffler
      Pages 433-448
    7. Hans-Joachim Merker, Jamaledin Ghaida, Dieter Blottner
      Pages 475-486
  7. Clinical Aspects of Risk Assessment

    1. Front Matter
      Pages 487-487
    2. Annette Grüters, Ulrich Bogner, Petra Schumm-Draeger, Hans Helge
      Pages 503-512
    3. Ulrich Wahn, Renate Bergmann, Maria-Elisabeth Herrmann, Annette Grüters, Werner Luck, Markos Schmitt
      Pages 513-518
    4. Hashem Abdul-Khaliq, Hugo Segerer, Michael Obladen
      Pages 519-526
    5. Ruth Hildebrandt
      Pages 527-535
    6. Reinhard Neubert, Isabella Delgado, Ursula Jacob-Müller, Joachim Wolfram Dudenhausen, Diether Neubert
      Pages 551-560
  8. Back Matter
    Pages 561-565

About these proceedings


Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.


Embryopharmacology Embryopharmakologie Embryotoxicology Embryotoxikologie research

Editors and affiliations

  • Diether Neubert
    • 1
  • Robert J. Kavlock
    • 2
  • Hans-Joachim Merker
    • 3
  • Jane Klein
    • 4
  1. 1.Institut für Toxikologie und EmbryopharmakologieUniversitätsklinikum Rudolf Virchow, Freie Universität BerlinBerlin 33Germany
  2. 2.Developmental Toxicology DivisionUS Environmental Protection Agency, Health Effects Research Laboratory (MD-71)USA
  3. 3.Institut für AnatomieFreie Universität BerlinBerlin 33Germany
  4. 4.Institut für Toxikologie und EmbryopharmakologieFreie Universität BerlinBerlin 33Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77755-4
  • Online ISBN 978-3-642-77753-0
  • Buy this book on publisher's site