Host Defense Dysfunction in Trauma, Shock and Sepsis

Mechanisms and Therapeutic Approaches

  • Eugen Faist
  • Jonathan L. Meakins
  • Friedrich W. Schildberg

Table of contents

  1. Front Matter
    Pages I-XXIV
  2. General Aspects/Perspectives

    1. Front Matter
      Pages 1-1
    2. J. A. Mannick
      Pages 15-21
    3. H. J. Dieterich, K. Peter
      Pages 31-35
  3. Host Defense Integrity-Response and Stress

  4. From Injury to Multiple Organ Failure: Sequential Steps of Host Defense Impairment

    1. Front Matter
      Pages 83-83
    2. Shock and Ischemia

      1. G. O. Till, P. A. Ward
        Pages 85-94
      2. G. F. Babcock, C. L. White-Owen, J. W. Alexander, G. D. Warden
        Pages 95-105
      3. G. Schlag, H. Redl
        Pages 139-147
      4. I. H. Chaudry, A. Ayala, D. Meldrum, W. Ertel
        Pages 149-159
    3. Intermediate Inflammatory Phase

      1. G. Regel, H. C. Pape, F. Koopmann, J. A. Sturm
        Pages 171-176
      2. P. A. Ward, M. S. Mulligan, J. S. Warren
        Pages 177-180
      3. S. R. Sharar, N. B. Vedder, W. J. Mileski, C. L. Rice, J. M. Harlan, R. K. Winn
        Pages 181-189
      4. D. Nast-Kolb, C. Waydhas, M. Jochum, M. Spannagl, W. Machleidt, K. H. Duswald et al.
        Pages 221-227
      5. T. Lindsay, J. Hill, C. R. Valeri, D. Shepro, H. B. Hechtman
        Pages 235-241
    4. Sepsis

      1. F. B. Taylor
        Pages 263-276
      2. H. Redl, G. Schlag, H. P. Dinges, R. Kneidinger, J. Davies
        Pages 277-286
      3. H. P. Friedl, O. Trentz, G. O. Till, P. A. Ward
        Pages 287-295
  5. Immune Mechanisms for the Control of Infection Under Physiologic and Stressful Conditions

    1. Front Matter
      Pages 309-309
    2. R. C. Bleackley
      Pages 311-316
    3. S. H. E. Kaufmann
      Pages 317-322
    4. D. H. Livingston, J. Hseih, T. Murphy, B. F. Rush Jr.
      Pages 339-348
    5. G. C. Spagnoli, M. Heberer, P. Vogelbach, R. Rosso, J. Jörgensen, F. Harder
      Pages 355-358
    6. A. Paccagnella, S. De Angeli, M. Mordacchini, G. Caenaro, A. Nieri, P. Rosi et al.
      Pages 359-364
    7. H. D. Volk, M. Thieme, U. Ruppe, S. Heym, W. D. Döcke, D. Manger et al.
      Pages 365-371
    8. E. Gotovtseva, I. Surkina, P. Uchakin, M. Shchurin, S. Pschenichkin, N. Kost et al.
      Pages 379-382
  6. Inflammatory Mechanisms in Traumatic and Septic Injury

    1. Front Matter
      Pages 383-383
    2. D. N. Herndon, T. C. Rutan, J. M. Mlakar, D. Fleming
      Pages 385-390

About this book


This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom­ panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.


Immundefizienz Sepsis Trauma alterations of the cytokine regulation antibiotics bacteria cytokine immunodeficiency immunoglobulin immunomodulation immunotherapy infection infections multiple organ failure shock

Editors and affiliations

  • Eugen Faist
    • 1
  • Jonathan L. Meakins
    • 2
  • Friedrich W. Schildberg
    • 1
  1. 1.Dept. of SurgeryLudwig-Maximilians-University MunichMunich 70Germany
  2. 2.Dept. of SurgeryMcGill UniversityMontrealCanada

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77407-2
  • Online ISBN 978-3-642-77405-8
  • Buy this book on publisher's site