Artificial Liver Support

Concepts, Methods, Results

  • G. Brunner
  • M. Mito

Table of contents

  1. Front Matter
    Pages I-XVI
  2. General Aspects of Hepatic Failure

    1. Front Matter
      Pages 1-1
    2. L. Zieve
      Pages 21-31
    3. J. F. R. Kerr, B. V. Harmon, J. Searle
      Pages 32-41
    4. B. J. Potter, P. D. Berk
      Pages 94-120
    5. M. Oellerich, M. Burdelski, R. Beyrau, B. Ringe, P. Lamesch, G. Gubernatis et al.
      Pages 132-139
    6. H. Nomura, P. S. Malchesky, Y. Nosé
      Pages 140-151
  3. Conservative Treatment

    1. Front Matter
      Pages 153-153
    2. S. Wagner, F. W. Schmidt
      Pages 155-162
  4. Hemoperfusion, Liver Perfusion, Dialysis, and Plasma Exchange

  5. Isolated and Immobilized Hepatocytes and Liver Tissue

  6. Enzymatic Liver Support and Lipophilic Hollow-Fiber Membranes

  7. Surgical Support and Transplantation

  8. Back Matter
    Pages 436-450

About this book


Continuing progress has been made since the first edition of Artificial Liver Support was published. Liver transplantation has however become an estab­ lished therapy for a relatively small number of patients who remain patients for life. There therefore continues to be a great need for the development of other forms of artificial liver support. Improved intensive care utilizing improved plasma exchange, dialysis, sclerotherapy, and intracranial pressure monitoring have improved survival in fulminant hepatic failure. Progress has also been made in lipid membrane detoxification, in cell cultures, and in cell transplantation, and the isolation of various liver cell growth factors has led to deep insight into the mechanisms of liver regeneration. This book gives the clinician and the researcher detailed information about established new methods of clinic work and laboratory research, and describes new experimental approaches indicating the direction of future research. G. BRUNNER M. Mno Preface to the First Edition The regenerative capacity of the liver cell is almost unlimited. Therefore after acute liver damage, be it viral, toxic, hypoxic, or surgical in origin, restitutio ad integrum is the usual outcome. In two forms of liver disease, however, this is not the case: in fulminant hepatic failure, liver regeneration often is not fast enough to keep the organism alive; in end-stage cirrhosis, regeneration is disturbed by a hypertrophic architecture of fibrotic tissue. For these extreme forms of liver disease and for critical situations before and after liver surgery, artificial liver support is needed.


Hepatologie Lebererkrankung Leberersatz Leberfunktionsstörung Liver Diseases cell chronic liver failure hepatic encephalopathy hepatology liver liver disease liver transplantation tissue transplantation

Editors and affiliations

  • G. Brunner
    • 1
  • M. Mito
    • 2
  1. 1.Abteilung für Gastroenterologie und HepatologieMedizinische Hochschule Hannover Krankenhaus OststadtHannover 51Germany
  2. 2.Second Department of SurgeryAsahikawa Medical College Nishi-KaguraHokkaidoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77361-7
  • Online ISBN 978-3-642-77359-4
  • Buy this book on publisher's site