Pathophysiology of Shock, Sepsis, and Organ Failure

  • Günther Schlag
  • Heinz Redl

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Introduction: “Organ in Shock”, “Early Organ Failure”, “Late Organ Failure”

  3. Trauma, Shock and Development of the Organ in Shock and Early Organ Failure (SIRS)

    1. Front Matter
      Pages 5-5
    2. M. Heideman, A. Bengtsson
      Pages 25-35
    3. M. Jochum, W. Machleidt, H. Neuhof, H. Fritz
      Pages 46-60
    4. Asrar B. Malik, Yan Wang
      Pages 61-78
    5. H. Redl, H. Gasser, S. Hallström, G. Schlag
      Pages 92-110
    6. D. B. Hoyt, W. G. Junger, A. N. Ozkan
      Pages 111-130
    7. R. Stephan, A. Ayala, I. H. Chaudry
      Pages 131-144
    8. J. Arnold, D. Leinhardt, R. A. Little
      Pages 145-160
    9. G. Schlag, H. Redl, J. Pretorius
      Pages 161-175
    10. M. Seyr, N. J. Mutz
      Pages 176-193
    11. D. L. Traber, J. Meyer, L. D. Traber
      Pages 194-199
    12. S. Hallström, B. Koidl, U. Müller, K. Werdan, G. Schlag
      Pages 200-214
    13. G. Gutierrez, S. D. Brown
      Pages 215-229
    14. G. I. J. M. Beerthuizen
      Pages 230-241
    15. C. S. Cox Jr., D. L. Traber, J. B. Zwischenberger, D. N. Herndon
      Pages 242-256
    16. H. P. Dinges, G. Schlag, H. Redl
      Pages 257-264
    17. M. R. Mainous, E. A. Deitch
      Pages 265-278
    18. G. Schlag, H. Redl, J. Davies, C. J. J. van Vuuren, P. Smuts
      Pages 279-291
    19. B. F. Rush Jr.
      Pages 292-299
    20. S. T. Zeigler, D. L. Traber, D. Herndon
      Pages 300-313
    21. U. Haglund
      Pages 314-321
    22. B. J. Zimmerman, H. Arndt, P. Kubes, H. Kurtel, D. N. Granger
      Pages 322-335
    23. J. C. Passmore, J. T. Fleming, A. E. Jimenez, R. N. Garrison, A. S. Lübbe
      Pages 336-351
    24. E. Kirkman, R. A. Little
      Pages 352-370
    25. I. H. Chaudry, P. Wang, G. Singh, J. G. Hauptman, A. Ayala
      Pages 371-383
    26. G. Schlag, H. Redl, Z. Khakpour, J. Davies, J. Pretorius
      Pages 384-402
  4. The Development of the Sepsis and Multi-Organ-Dysfunction-Syndrome (MODS)

    1. Front Matter
      Pages 403-403
    2. H. Loppnow, H.-D. Flad, E. T. Rietschel, H. Brade
      Pages 405-416
    3. A. O. Aasen
      Pages 417-426
    4. W. Seeger, N. Suttorp, F. Grimminger, S. Bhakdi
      Pages 427-446
    5. A. Bengtsson, H. Redl, G. Schlag
      Pages 447-458
    6. H. Redl, G. Schlag, S. Bahrami, J. Davies, A. Waage, M. Ceska et al.
      Pages 468-490
    7. A. Waage, H. Redl, G. Schlag, U. Schade
      Pages 491-501
    8. D. Hosford, M. Koltai, P. Braquet
      Pages 502-517
    9. J. A. Cook, J. Geisel, G. E. Tempel, W. C. Wise, P. V. Halushka
      Pages 518-530
    10. M. Jochum, W. Machleidt, H. Fritz
      Pages 531-548
    11. H. Redl, G. Schlag, R. Kneidinger, H. P. Dinges, J. Davies
      Pages 549-563
    12. J. H. Morrissey, T. A. Drake
      Pages 564-574
    13. G. J. Bagby, C. H. Lang, J. J. Spitzer
      Pages 593-608
    14. J. H. Siegel, S. Goodzari, P. Guadelupi, W. P. Coleman, D. Malcolm, S. Blevins et al.
      Pages 626-664
    15. S. Bahrami, G. Schlag
      Pages 665-675

About this book


In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.


Anästhesie Organversagen Sepsis Trauma Unfallchirurgie antibiotic care intensive care intensive care medicine multiple organ failure pathophysiology physiology shock surgery traumatology

Editors and affiliations

  • Günther Schlag
    • 1
  • Heinz Redl
    • 1
  1. 1.Ludwig-Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76738-8
  • Online ISBN 978-3-642-76736-4
  • Buy this book on publisher's site