Epidemiology and Biology of Multiple Myeloma

  • G. Iris Obrams
  • Michael Potter

Table of contents

  1. Front Matter
    Pages I-XV
  2. Descriptive and Analytical Epidemiology

    1. Front Matter
      Pages 1-1
    2. Leon F. Burmeister
      Pages 17-22
    3. Richard P. Gallagher, Diane H. Skippen
      Pages 23-26
    4. E. F. Heineman, J. Olsen, L. M. Pottern, M. R. Gomez, E. Raffn, A. Blair
      Pages 27-29
    5. A. F. Olshan
      Pages 31-39
  3. Black/White Differences in Risk

    1. Front Matter
      Pages 41-41
    2. David J. Tollerud, Linda Morris Brown, William A. Blattner, Robert N. Hoover
      Pages 45-49
    3. C. S. Glover, J. Horm, G. Christenson
      Pages 55-60
    4. Robert J. Jacobson
      Pages 69-71
  4. Monoclonal Gammopathies and Multiple Myeloma

    1. Front Matter
      Pages 73-73
    2. J. R. Berenson, A. K. Lichtenstein, J. Cao, S. Hart, D. Palomares, R. A. Miller
      Pages 87-96
  5. Etiologic Hypotheses

    1. Front Matter
      Pages 98-98

About these proceedings

Introduction

On March 27, 1990, the National Cancer Institute sponsored a workshop on the epidemiology of multiple myeloma, held at the National Institutes of Health. This book comprises articles prepared by participants in this work­ shop. Discussed in these papers are: the descriptive and analytic epidemi­ ology, differences in risk factors between blacks and whites, monoclonal gammopathies and their progression, and hypotheses regarding the etiology and pathogenesis of multiple myeloma. Several epidemiologic research areas received particular attention during this workshop, and are reviewed in detail in this volume. There have been striking increases in the incidence of multiple myeloma over the past thirty years, especially among older individuals and blacks, which may not be entirely explained by changes in diagnostic capabilities. Occupational and environmental exposures have been associated with an increased risk of multiple myeloma, including farming exposures, occupational exposure to petroleum and rubber processing, exposure to ionizing radiation, and asso­ ciations with persistent virus infections. The most striking epidemiological finding is reflected in the differences in incidence rates of multiple myeloma which are twice as high in blacks as compared with whites. Further, since 1950 the mortality rates for multiple myeloma have quadrupled in blacks while doubling for whites. Among hematopoietic malignancies, multiple myeloma is the only one with increased incidence and mortality rates among blacks. 1\vo major possibilities for explaining ethnic/racial differences in suscepti­ bility to multiple myeloma are genetic and environmental factors.

Keywords

Epidemiologie Etiologie Hematopoietic Cancer Multiple Myeloma Plasmozytom cancer cell cytogenetics epidemiology etiology genetics mortality pathogenesis plasma

Editors and affiliations

  • G. Iris Obrams
    • 1
  • Michael Potter
    • 2
  1. 1.Epidemiology & Biostatistics Program, Division of Cancer EtiologyNational Cancer InstituteBethesdaUSA
  2. 2.Division of Cancer Biology, Diagnosis, and CentersNational Cancer InstituteBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76655-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76657-2
  • Online ISBN 978-3-642-76655-8
  • About this book