Acute Leukemias

Pharmacokinetics and Management of Relapsed and Refractory Disease

  • W. Hiddemann
  • T. Büchner
  • B. Wörmann
  • W. Plunkett
  • M. Keating
  • M. Andreeff
Conference proceedings

Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 34)

Table of contents

  1. Front Matter
    Pages I-XXVI
    PDF

  2. Drug Resistance in Leukemia

    1. Front Matter
      Pages 1-1
      PDF
    2. Multidrug Resistance and Its Circumvention in Acute Leukemia
      A. F. List, C. M. Spier, W. S. Dalton
      Pages 3-10
    3. The Role of DNA Topoisomerase II in Multidrug Resistance in Human Leukemia
      W. T. Beck, T. Funabiki, M. K. Danks
      Pages 11-15
    4. Development of Sensitive Assays to Detect Antifolate Resistance in Leukemia Blasts
      T. Trippett, J. T. Lin, Y. Elisseyeff, M. Wachter, S. Schlemmer, B. Schweitzer et al.
      Pages 16-22
    5. Sequential Analysis of P-Glycoprotein Expression in Childhood Acute Lymphoblastic Leukemia
      D. Kingreen, C. Sperling, M. Notter, C. Schmidt, H. Diddens, H. Riehm et al.
      Pages 23-28
    6. Expression of the MDR1 Gene and Treatment Outcome in Acute Nonlymphocytic Leukemia
      R. Pirker, J. Wallner, K. Geissler, P. Bettelheim, W. Linkesch, K. Lechner
      Pages 29-32
    7. Multidrug Resistance Proteins and their Functional Modulation in Human Leukemias as Analyzed by Flow Cytometry
      L. Van Hove, K. Van Acker, M. Boogaerts
      Pages 33-39
    8. Reversal of Multidrug Resistance with a New Calcium/Calmodulin Antagonist
      E. Roller, B. Benz, M. Eichelbaum, V. Gekeler, K. Häußermann, B. Klumpp et al.
      Pages 40-43
    9. Characterization of Human Leukemic HL-60 Sublines as a Model for Primary and Secondary Resistance Against Cytostatics
      E. Gieseler, F. Boege, R. Erttmann, H.-P. Tony, H. Biersack, B. Spohn et al.
      Pages 44-48
    10. Conserved Cytotoxic Activity of Aclacinomycin A in Multifactorial Multidrug Resistance
      R. Erttmann, A. Boetefür, K. D. Erttmann, F. Gieseler, G. Looft, M. Münchmeyer et al.
      Pages 49-55
    11. Cytostatic Drug Resistance and Differentiation in Friend Erythroleukemia Cells
      C. A. Schmidt, A. Schäfer, F. Lorenz, H. Oettle, F. F. Wilborn, D. Huhn et al.
      Pages 56-59
    12. On the Role of Aldehyde Dehydrogenase in a Cyclophosphamide-Resistant Variant of Brown Norway Rat Acute Myelocytic Leukemia
      C. J. de Groot, A. C. M. Martens, A. Hagenbeek
      Pages 60-64
    13. SAENTA-fluoresceins: New Flow Cytometry Reagents for Assessing Transport of Nucleoside Drugs in Acute Leukemia
      J. S. Wiley, G. P. Jamieson, A. M. Brocklebank, M. B. Snook, W. H. Sawyer, P. M. Dennington et al.
      Pages 65-71

  3. Hematopoietic Growth Factors in Leukemia Therapy

    1. Front Matter
      Pages 73-73
      PDF
    2. Human Stem Cell Factor: Biological Effects and Receptor Expression on Myeloid Leukemia Cells
      T. Pietsch, U. Kyas, K. Zsebo, K. Welte
      Pages 75-80
    3. Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Following Chemotherapy in Patients with High-Risk AML
      T. Büchner, W. Hiddemann, M. Koenigsmann, M. Zühlsdorf, B. Wörmann, A. Boeckmann et al.
      Pages 81-96
    4. Use of Granulocyte-Macrophage Colony-Stimulating Factor Prior to Chemotherapy of Newly Diagnosed AML
      E. Estey, H. Kantarjian, S. O’Brien, M. Beran, K. McCredie, C. Koller et al.
      Pages 97-100
    5. G-CSF after Intensive Induction Chemotherapy in Refractory Acute Leukemia and Bone Marrow Transplantation in Myeloid Leukemia
      R. Ohno, T. Masaoka, S. Asano, F. Takaku
      Pages 101-107
    6. Cytokinetic Resistance in Acute Leukemia: Recombinant Human Granulocyte Colony-Stimulating Factor, Granulocyte Macrophage Colony-Stimulating Factor, Interleukin-3 and Stem Cell Factor Effects In Vitro and Clinical Trials with Granulocyte Macrophage Colony-Stimulating Factor
      M. Andreeff, A. Tafuri, P. Bettelheim, P. Valent, E. Estey, R. Lemoli et al.
      Pages 108-117

About these proceedings

Keywords

bone marrow cell cell biology chemotherapy cytogenetics drug drug resistance genetics immunotherapy kinetics leukemia pharmacokinetics resistance stem cell transplantation

Editors and affiliations

  • W. Hiddemann
    • 1
  • T. Büchner
    • 1
  • B. Wörmann
    • 1
  • W. Plunkett
    • 2
  • M. Keating
    • 2
  • M. Andreeff
    • 2
  1. 1.Department of Internal MedicineUniversity of MünsterMünsterFederal Republic of Germany
  2. 2.M. D. Anderson Cancer CenterUniversity of TexasHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-76591-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-53949-0
  • Online ISBN 978-3-642-76591-9
  • Series Print ISSN 0440-0607
  • Buy this book on publisher's site