Rheumatoid Arthritis

Recent Research Advances

  • Josef S. Smolen
  • Joachim R. Kalden
  • Ravinder N. Maini
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XX
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Genetics

    1. Front Matter
      Pages 15-15
    2. J. S. S. Lanchbury, L. I. Sakkas, G. S. Panayi
      Pages 17-28
    3. H. M. Moutsopoulos, P. G. Vlachoyiannopoulos
      Pages 29-37
  4. Pathogenesis

    1. Front Matter
      Pages 39-39
    2. M. Feldmann, F. M. Brennan, M. Field, R. N. Maini
      Pages 41-54
    3. Ø. Førre, K. Waalen, J. B. Natvig
      Pages 71-90
    4. C. Plater-Zyberk, R. N. Maini, F. M. Brennan, M. Feldmann
      Pages 122-136
    5. P. Youinou, A. Lamour, A. Dumay, P. Le Goff
      Pages 150-163
  5. Etiologic Factors — Bacterial Antigens, Autoantigens, Viruses

    1. Front Matter
      Pages 165-165
    2. W. van Eden, C. J. P. Boog, E. J. M. Hogervorst, M. H. M. Wauben, R. van der Zee, J. D. A. van Embden
      Pages 167-179
    3. L. J. Crofford, R. L. Wilder
      Pages 202-215
    4. E. Peterhans, B. Pohl, R. Zanoni, S. Lazary
      Pages 216-230
    5. G. Stransky, R. E. Gay, A. Trabandt, W. K. Aicher, S. R. Barnum, S. Gay
      Pages 231-243
    6. M. Lotz, J. Roudier
      Pages 257-280
  6. Autoantibodies and Markers of Disease Activity

    1. Front Matter
      Pages 297-297
    2. W. Hassfeld, G. Steiner, W. Graninger, J. S. Smolen
      Pages 319-327
    3. G. Husby
      Pages 328-347
    4. F. A. Wollheim, T. Saxne
      Pages 348-362
  7. Therapy

    1. Front Matter
      Pages 363-363
    2. F. C. Breedveld, R. R. P. de Vries
      Pages 385-393
  8. Back Matter
    Pages 395-399

About these proceedings


Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.


Arthritis Immungenetik antibody antigen autoimmunity bacteria cartilage genetics immune response immunity infection inflammation joint rheumatism rheumatoid arthritis

Editors and affiliations

  • Josef S. Smolen
    • 1
  • Joachim R. Kalden
    • 2
  • Ravinder N. Maini
    • 3
  1. 1.2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer ErkrankungenKrankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und BalneologieWienAustria
  2. 2.Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und RheumatologieFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany
  3. 3.Mathilda and Terence Kennedy Institute of RheumatologyHammersmith, LondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-76191-1
  • Online ISBN 978-3-642-76189-8
  • Buy this book on publisher's site