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Recent Progress in the Genetic Epidemiology of Cancer

  • Henry T. Lynch
  • Petre Tautu
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XI
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. H. T. Lynch, J. F. Lynch
      Pages 3-17
  3. Studies on Genetic Epidemiology

    1. Front Matter
      Pages 27-27
    2. N. Andrieu, F. Clavel, F. Demenais
      Pages 29-35
    3. D. T. Bishop, L. A. Cannon-Albright, M. H. Skolnick
      Pages 36-48
    4. C. Bonaïti-Pellié, F. Clerget-Darpoux, M.-C. Babron
      Pages 49-56
    5. L. A. Cannon-Albright, D. T. Bishop, D. E. Goldgar, M. H. Skolnick
      Pages 57-65
    6. M. Mannens, J. Hoovers, E. M. Bleeker-Wagemakers, J. Bliek, B. Redeker, R. John et al.
      Pages 78-88
    7. S. A. Seuchter, M. Knapp, M. P. Baur
      Pages 89-94
  4. Computer Applications

    1. Front Matter
      Pages 133-133
  5. Back Matter
    Pages 155-164

About these proceedings

Introduction

The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit­ ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi­ tioned at the intersection of molecular genetics, population gen­ etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole­ cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree.

Keywords

Biostatistik Cancer genetics Chromosom Genetik Medizinische Informatik Onkologische Epidemiologie Retinoblastom biostatistics cancer cancer epidemiology computer science epidemiology genetic epidemiology genetics

Editors and affiliations

  • Henry T. Lynch
    • 1
  • Petre Tautu
    • 2
  1. 1.Department of Preventive Medicine/Public HealthCreighton University Medical SchoolOmahaUSA
  2. 2.Institut für Epidemiologie und BiometrieDeutsches KrebsforschungszentrumHeidelbergGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75993-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-53022-0
  • Online ISBN 978-3-642-75993-2
  • Buy this book on publisher's site