Mechanisms in B-Cell Neoplasia 1990

Workshop at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990

  • Michael Potter
  • Fritz Melchers

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Table of contents

  1. Front Matter
    Pages I-XIX
  2. IL-6 in Multiple Myeloma

    1. Front Matter
      Pages 1-1
    2. K. Nilsson, H. Jernberg, M. Pettersson
      Pages 3-12
    3. S. Suematsu, M. Hibi, T. Sugita, M. Saito, M. Murakami, T. Matsusaka et al.
      Pages 13-22
    4. Brian G. M. Durie, Elizabeth E. Vela, Yvette Frutiger
      Pages 33-36
    5. D. Emilie, M. Peuchmaur, P. Galanaud
      Pages 47-49
  3. Experimental Plasmacytomas and B-Cell Tumors

    1. Front Matter
      Pages 75-75
    2. Richard G. Hoover, Sheryl Roman, Jonni S. Moore, Christine Darby, Susan Müller
      Pages 77-85
    3. David Largaespada, Donal Kaehler, Evi Weissinger, Harold Mischak, Fred Mushinski, Rex Risser
      Pages 91-96
    4. S. Silva, H. Sugiyama, M. Babonits, F. Wiener, G. Klein
      Pages 97-105
    5. F. Wiener, S. Silva, H. Sugiyama, M. Babonits, H. Axelson, P. Chinmay et al.
      Pages 107-119
    6. E. M. Weissinger, D. Largaespada, S. J. Smith-Gill, R. Risser, J. F. Mushinski, H. Mischak
      Pages 121-127
    7. U. R. Rapp, J. Troppmair, M. Carroll, S. May
      Pages 129-139
    8. C. Timblin, P. L. Bergsagel, W. M. Kuehl
      Pages 141-147
    9. W. Y. Langdon, T. J. Blake
      Pages 159-164
    10. A. W. Harris, M. L. Bath, H. Rosenbaum, J. McNeall, J. M. Adams, S. Cory
      Pages 165-173
    11. A. Strasser, A. W. Harris, D. L. Vaux, E. Webb, M. L. Bath, J. M. Adams et al.
      Pages 175-181
  4. Growth Regulation to B-Cells: Immortalization

    1. Front Matter
      Pages 183-183
    2. R. W. Overell, K. E. Weisser, B. Hess, R. Goodwin, L. Clark, K. H. Grabstein
      Pages 185-188
    3. Stanley J. Korsmeyer, Timothy J. McDonnell, Gabriel Nunez, David Hockenbery, Robert Young
      Pages 203-207
  5. C-myc Genes in B- Cell Neoplasia

    1. Front Matter
      Pages 209-209
    2. M. P. Duyao, D. J. Kessler, D. B. Spicer, G. E. Sonenshein
      Pages 211-220
    3. K. Huppi, D. Siwarski, R. M. Skurla Jr., J. Goodnight, J. F. Mushinski
      Pages 233-241
    4. J. F. Mushinski, R. M. Skurla Jr., J. Goodnight, D. Siwarski, K. Huppi
      Pages 243-249
    5. Alasdair J. Street, Elizabeth Blackwood, Bernhard Lüscher, Robert N. Eisenman
      Pages 251-258
    6. E. H. Humphries, E. J. Filardo
      Pages 259-265
    7. M. Zajac-Kaye, B. Yu, N. Ben-Baruch
      Pages 279-284
    8. E. J. Beecham, J. F. Mushinski, E. Shacter, M. Potter, V. A. Bohr
      Pages 285-291
    9. Luigia Lombardi, Francesco Grignani, Lars Sternas, Katarina Cechova, Giorgio Inghirami, Riccardo Dalla-Favera
      Pages 293-301
  6. Role of EBV in B-Cell Neoplasia

About this book


The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.


Burkitt's Lymphoma Lymphome Myelome Neoplasie Onkologie Tumoren oncology plasma cells tumorigenesis tumors

Editors and affiliations

  • Michael Potter
    • 1
  • Fritz Melchers
    • 2
  1. 1.Laboratory of Genetics, National Institutes of HealthNational Cancer InstituteBethesdaUSA
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75891-1
  • Online ISBN 978-3-642-75889-8
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site