The Endothelins

  • Winifred G. Nayler

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Winifred G. Nayler
    Pages 10-19
  3. Winifred G. Nayler
    Pages 21-29
  4. Winifred G. Nayler
    Pages 31-37
  5. Winifred G. Nayler
    Pages 39-48
  6. Winifred G. Nayler
    Pages 75-78
  7. Winifred G. Nayler
    Pages 80-89
  8. Winifred G. Nayler
    Pages 98-106
  9. Winifred G. Nayler
    Pages 107-115
  10. Winifred G. Nayler
    Pages 116-127
  11. Winifred G. Nayler
    Pages 128-138
  12. Winifred G. Nayler
    Pages 139-147
  13. Winifred G. Nayler
    Pages 154-159
  14. Winifred G. Nayler
    Pages 160-162
  15. Winifred G. Nayler
    Pages 163-163
  16. Back Matter
    Pages 165-183

About this book


"What we call the beginning is often the end, and to make an end is to make a beginning. The end is where we start from." T. S. ELIOT, "Geroniton" The discovery of endothelin-l was both an end and a beginning. It is an end because this discovery has started a plethora of investigations as to endothe1in's sites of production, mode of action, it's normal and abnormal physiological role and its involvement in a variety of pathological conditions ranging from renal failure to myocardial infarction, cardiac hypertrophy, hyperten­ sion, cyclosporine induced toxicity, mental depression, renal failure, stress related illness, and even stroke and sudden death. It is a beginning because no one can foresee where the investigations will ultimately lead, or how they will end. The discovery of the endothelins was a very recent event and soon specialist books will start to appear dealing in detail with different aspects of their chemistry, physiological role and pathological importance. The present book is intended to act as a guide and primer for those who are becoming intrigued by the many endothelin­ related articles which are now appearing in the journals but who as yet have not had the time or opportunity to be caught up in the web of enthusiasm and excitement which is motivating those more directly involved in the field of research.


Calcium artery atherosclerosis chemistry circulation endothelium heart heart disease hypertension kidney metabolism platelet receptor synthesis tissue

Authors and affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75874-4
  • Online ISBN 978-3-642-75872-0
  • Buy this book on publisher's site