Overview
- Authors:
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Adam Schneeweiss
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Tel Aviv, Israel
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Marija Weiss
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Köln 71, Germany
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Table of contents (28 chapters)
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Nitrate Formulations and Routes of Administration
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- Adam Schneeweiss, Marija Weiss
Pages 101-108
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- Adam Schneeweiss, Marija Weiss
Pages 109-110
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- Adam Schneeweiss, Marija Weiss
Pages 111-114
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- Adam Schneeweiss, Marija Weiss
Pages 115-117
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- Adam Schneeweiss, Marija Weiss
Pages 118-129
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- Adam Schneeweiss, Marija Weiss
Pages 130-150
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- Adam Schneeweiss, Marija Weiss
Pages 151-152
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Pharmacology
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Front Matter
Pages 153-153
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- Adam Schneeweiss, Marija Weiss
Pages 155-165
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- Adam Schneeweiss, Marija Weiss
Pages 166-172
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- Adam Schneeweiss, Marija Weiss
Pages 173-177
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Conclusions
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- Adam Schneeweiss, Marija Weiss
Pages 179-179
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Back Matter
Pages 181-206
About this book
Nitrates have been for many years the cornerstone of cardiovascular therapy for various indications. Not only have nitrates stood the test of time for treatment of chronic stable angina pectoris, but the indications for them have markedly ex panded. They now include all forms of angina pectoris and myocardial ischemia, congestive heart failure and hypertensive emergencies. The beneficial effects of nitrates in all these conditions result from their vasodilatory properties, but it is still unclear whether the central or peripheral effects predominate in the thera peutic mechanism. Recently nitrates have been shown to fulfill the most important requirement for each and every drug - to reduce mortality. A large scale study revealed that isosorbide dinitrate, combined with hydralazine, reduced long-term mortality by 28% in patients with congestive heart failure. This finding will certainly stimulate research on nitrates, and it might be expected that interest in these drugs will markedly increase. The primarily used nitrates in clinical practice are nitroglycerin and the com plex organic nitrates, mainly isosorbide dinitrate. The organic mononitrates are now under clinical investigation, and isosorbide-5-mononitrate (IS-5-MN) appears to be especially promising.
Authors and Affiliations
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Tel Aviv, Israel
Adam Schneeweiss
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Köln 71, Germany
Marija Weiss
