Advertisement

Advances in Nitrate Therapy

  • Adam Schneeweiss
  • Marija Weiss

Table of contents

  1. Front Matter
    Pages I-VI
  2. Introduction and Mechanism

    1. Front Matter
      Pages 1-1
    2. Adam Schneeweiss, Marija Weiss
      Pages 3-5
    3. Adam Schneeweiss, Marija Weiss
      Pages 6-8
  3. Indications

    1. Front Matter
      Pages 9-9
    2. Adam Schneeweiss, Marija Weiss
      Pages 11-13
    3. Adam Schneeweiss, Marija Weiss
      Pages 14-23
    4. Adam Schneeweiss, Marija Weiss
      Pages 24-37
    5. Adam Schneeweiss, Marija Weiss
      Pages 38-42
    6. Adam Schneeweiss, Marija Weiss
      Pages 43-52
    7. Adam Schneeweiss, Marija Weiss
      Pages 53-54
    8. Adam Schneeweiss, Marija Weiss
      Pages 55-63
    9. Adam Schneeweiss, Marija Weiss
      Pages 64-69
    10. Adam Schneeweiss, Marija Weiss
      Pages 70-72
    11. Adam Schneeweiss, Marija Weiss
      Pages 73-76
    12. Adam Schneeweiss, Marija Weiss
      Pages 84-87
    13. Adam Schneeweiss, Marija Weiss
      Pages 88-91
    14. Adam Schneeweiss, Marija Weiss
      Pages 92-93
    15. Adam Schneeweiss, Marija Weiss
      Pages 94-98
  4. Nitrate Formulations and Routes of Administration

    1. Front Matter
      Pages 99-99
    2. Adam Schneeweiss, Marija Weiss
      Pages 101-108
    3. Adam Schneeweiss, Marija Weiss
      Pages 109-110
    4. Adam Schneeweiss, Marija Weiss
      Pages 111-114
    5. Adam Schneeweiss, Marija Weiss
      Pages 115-117
    6. Adam Schneeweiss, Marija Weiss
      Pages 118-129
    7. Adam Schneeweiss, Marija Weiss
      Pages 130-150
    8. Adam Schneeweiss, Marija Weiss
      Pages 151-152
  5. Pharmacology

    1. Front Matter
      Pages 153-153
    2. Adam Schneeweiss, Marija Weiss
      Pages 155-165
    3. Adam Schneeweiss, Marija Weiss
      Pages 166-172
    4. Adam Schneeweiss, Marija Weiss
      Pages 173-177
  6. Conclusions

    1. Adam Schneeweiss, Marija Weiss
      Pages 179-179
  7. Back Matter
    Pages 181-206

About this book

Introduction

Nitrates have been for many years the cornerstone of cardiovascular therapy for various indications. Not only have nitrates stood the test of time for treatment of chronic stable angina pectoris, but the indications for them have markedly ex­ panded. They now include all forms of angina pectoris and myocardial ischemia, congestive heart failure and hypertensive emergencies. The beneficial effects of nitrates in all these conditions result from their vasodilatory properties, but it is still unclear whether the central or peripheral effects predominate in the thera­ peutic mechanism. Recently nitrates have been shown to fulfill the most important requirement for each and every drug - to reduce mortality. A large scale study revealed that isosorbide dinitrate, combined with hydralazine, reduced long-term mortality by 28% in patients with congestive heart failure. This finding will certainly stimulate research on nitrates, and it might be expected that interest in these drugs will markedly increase. The primarily used nitrates in clinical practice are nitroglycerin and the com­ plex organic nitrates, mainly isosorbide dinitrate. The organic mononitrates are now under clinical investigation, and isosorbide-5-mononitrate (IS-5-MN) appears to be especially promising.

Keywords

Bluthochdruck Medikament Nitrate angina pectoris arrhythmia cardiovascular congenital heart disease drug drugs heart heart failure hypertension medikamentöse Behandlung myocardial infarction pharmacology

Authors and affiliations

  • Adam Schneeweiss
    • 1
  • Marija Weiss
    • 2
  1. 1.Tel AvivIsrael
  2. 2.Köln 71Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75834-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75836-2
  • Online ISBN 978-3-642-75834-8
  • Buy this book on publisher's site