Recent Progress in the Chemical Synthesis of Antibiotics

  • G. Lukacs
  • M. Ohno

Table of contents

  1. Front Matter
    Pages i-xii
  2. Kuniaki Tatsuta
    Pages 1-38
  3. T. Blizzard, M. H. Fisher, H. Mrozik, T. L. Shih
    Pages 65-102
  4. Minoru Isobe
    Pages 103-134
  5. J. M. Paris, J. C. Barrière, C. Smith, P. E. Bost
    Pages 183-248
  6. Daniel Bouzard
    Pages 249-283
  7. Bert Fraser-Reid, J. Cristobal Lopez
    Pages 285-319
  8. Federico G. De las Heras, María José Camarasa, José Fiandor
    Pages 321-363
  9. Adam Gołebiowski, Janusz Jurczak
    Pages 365-385
  10. William A. Remers, Bhashyam S. Iyengar
    Pages 415-445
  11. Osamu Yonemitsu, Kiyoshi Horita
    Pages 447-466
  12. Gareth J. Thomas
    Pages 467-496
  13. A. V. Rama Rao
    Pages 497-531
  14. Ettore Perrone, Giovanni Franceschi
    Pages 613-703
  15. Masayuki Narisada, Teruji Tsuji
    Pages 705-725

About this book

Introduction

The use of antibiotics in the treatment by antibacterial and antifungal chemo­ therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange­ ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

Keywords

AIDS Antibiotikum Chemische Synthese antibiotics aromatic cancer chemistry research synthesis

Editors and affiliations

  • G. Lukacs
    • 1
  • M. Ohno
    • 2
  1. 1.Institut de Chimie des Substances Naturelles du C.N.R.S.Gif-sur-Yvette CedexFrance
  2. 2.University of TokyoBunkyo-ku Tokyo 113Japan

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-75617-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75619-1
  • Online ISBN 978-3-642-75617-7
  • About this book