Advertisement

Bacterial Capsules

  • Klaus Jann
  • Barbara Jann

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 150)

Table of contents

  1. Front Matter
    Pages I-IX
  2. G. J. Boulnois, I. S. Roberts
    Pages 1-18
  3. F. Ørskov, I. Ørskov
    Pages 43-63
  4. Back Matter
    Pages 159-162

About these proceedings

Introduction

Many bacteria, such as certain Neisseria and Haemophilus or Escherichia coli, are able to withstand the bactericidal activity of complement and phagocytes. This bacterial self protection is brought about by encapsulation. Bacterial capsules thus enable the pathogenic bacteria to survive in the host by counter­ action or evasion of the nonspecific host defense in the early pre immune phase of an infection. It is only in the late immune phase of the infection, when specific anticapsular antibodies are formed and enforce the host's defense system, that this protective action is overcome. Encapsulated bacteria are then killed and eliminated. Interestingly, some capsules can not or only inefficiently be handled by the immune system. The ensuing lack of antibody formation results in a prolonged susceptibility of the host to the pathogenic bacteria exhibiting such capsules. It was found that bacterial capsules consist of acidic poly­ saccharides. From this it followed that the role of the capsules in the interaction of encapsulated bacteria with the host may be due to the chemistry of the capsular polysaccharides. This led to intensive studies of capsular polysaccharides in many laboratories. Our increasing knowledge of the structural features of capsular polysaccharides prompted not only immuno­ chemical studies analyzing the interactions of these poly­ saccharide antigens and characterizing the epitopes, but also investigations into their biosynthesis. These studies were complemented and supported by genetic analyses. Today many interdisciplinary investigations of capsular polysaccharides are in progress.

Keywords

Antigene Antigenes Gene organisation Genorganisation Infection Infektionen Kapselpolysaccharide Polysaccharid Polysaccharide capsules biochemistry microbiology

Editors and affiliations

  • Klaus Jann
    • 1
  • Barbara Jann
    • 1
  1. 1.Max-Planck-Institut für ImmunbiologieFreiburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-74694-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-74696-3
  • Online ISBN 978-3-642-74694-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site