Gallstone Disease

Pathophysiology and Therapeutic Approaches

  • W. Swobodnik
  • R. D. Soloway
  • H. Ditschuneit
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Pathobiochemistry and Pathophysiology of Gallstone Development: Importance for Clinical Decision Processes

  3. Different Therapeutic Approaches to Gallstone Disease

    1. Front Matter
      Pages 93-93
    2. W. Oettinger, K. Orth, B. Leibl
      Pages 99-101
    3. P. Malfertheiner
      Pages 109-114
    4. Systemic Litholysis with Bile Acids

      1. M. Podda, M. Zuin, M. L. Petroni, E. Bertolini, A. Crosignani, G. Grandinetti
        Pages 127-133
      2. P. Janowitz, W. Swobodnik, J. G. Wechsler, S. Fischer, J. Tudyka, H. Ditschuneit
        Pages 135-145
    5. Extracorporeal Shock-Wave-Lithotripsy

      1. U. Faust
        Pages 147-159
      2. G. Paumgartner, M. Sackmann, J. Holl, T. Sauerbruch
        Pages 161-164
      3. M. Staritz, A. Rambow, A. Floth, P. Mildenberger, M. Goebel, T. Junginger et al.
        Pages 165-170
      4. C. Ell, W. Kerzel, H. T. Schneider, W. Domschke, E. G. Hahn
        Pages 171-176
    6. Laser Lithotripsy

      1. R. Steiner, Th. Meier
        Pages 195-200
      2. C. Ell, J. Hochberger, E. G. Hahn, L. Demling
        Pages 201-204
    7. Local Litholysis

      1. J. L. Thistle, B. T. Petersen, J. E. McCullough, C. E. Bender, A. J. LeRoy
        Pages 205-209
      2. K. Draese, J. Schopohl, C. E. Zöckler, S. Martin
        Pages 217-223
    8. New Therapeutic Trends

  4. Back Matter
    Pages 249-254

About these proceedings


The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predom­ inantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overview of the pathophysiologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New information concerning the balance between vesicular and micellar transport of choles­ terol, early cholesterol nucleation, and the influence of inhibiting and promoting com­ pounds for cholesterol nucleation as well as information concerning the effects of changes in gallbladder motility and gallbladder mucosal function is reviewed. In order to make further progress in developing treatments which facilitate gallstone dissolution and in preventing disease, it is necessary to integrate this new data into our thinking. Methods of treatment such as systemic litholysis of cholesterol gallbladder stones with bile acid preparations and mechanical fragmentation of stones either by extracorpo­ ral shock waves or intracorporal laser systems are carefully described and separate discussions of direct contact litholysis of cholesterol stones with ether preparations and the local litholytic treatment of calcified pigment stones are included. New therapeutic applications of HMG-CoA-reductase inhibitors and nonsteroidal anti-inflammatory drugs are also critically reviewed. Finally, for the interested reader an evaluation of prophylactic treatment against stone recurrence after successful conservative treatment and an appraisal of alternative management strategies supplement the information on the conservative treatment of gallstones.


extracorporal shock waves gallstones litholysis pathophysiology physiology therapy ultrasound

Editors and affiliations

  • W. Swobodnik
    • 1
  • R. D. Soloway
    • 2
  • H. Ditschuneit
    • 1
  1. 1.Abteilung Innere Medizin II, Gastroenterologie und ErnährungswissenschaftenUniversitätsklinikum UlmUlmGermany
  2. 2.Division of GastroenterologyUniversity of Texas Medical Branch at GalvestonGalvestonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1990
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-50965-3
  • Online ISBN 978-3-642-74619-2
  • Buy this book on publisher's site