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Pharmacology of the Skin I

Pharmacology of Skin Systems Autocoids in Normal and Inflamed Skin

  • Malcolm W. Greaves
  • Sam Shuster

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)

Table of contents

  1. Front Matter
    Pages I-XXIX
  2. Pharmacology of Skin Systems

    1. Front Matter
      Pages 1-1
    2. E. Christophers, C. Schubert, M. Goos
      Pages 3-30
    3. H. P. Baden
      Pages 31-44
    4. E. M. Saihan
      Pages 45-58
    5. C. M. Lapière, B. V. Nusgens
      Pages 69-88
    6. D. I. Abramson
      Pages 89-116
    7. M. J. Forrest, T. J. Williams
      Pages 117-127
    8. M. K. Church, R. C. Benyon, L. S. Clegg, S. T. Holgate
      Pages 129-166
    9. J. Morley
      Pages 167-173
    10. K. J. Collins
      Pages 193-212
    11. W. I. Cranston
      Pages 213-221
    12. R. P. R. Dawber
      Pages 223-232
    13. A. J. Thody, S. Shuster
      Pages 233-246
    14. F. Wright, P. Mauvais-Jarvis
      Pages 247-255
    15. K. A. Brown, B. A. Ellis, D. C. Dumonde
      Pages 271-286
  3. Autocoids in Normal and Inflamed Skin

    1. Front Matter
      Pages 287-287
    2. J. C. Foreman
      Pages 289-308
    3. V. Eisen
      Pages 309-330
    4. S. I. Wasserman
      Pages 367-375
    5. A. G. Bird
      Pages 377-394
    6. S. D. Brain, J. A. Edwardson
      Pages 409-422
    7. J. C. Allen
      Pages 423-439
    8. G. Volden, V. K. Hopsu-Havu
      Pages 441-464
    9. C. J. Dunn, D. A. Willoughby
      Pages 465-477
    10. M. W. Greaves, F. Lawlor
      Pages 479-494
  4. Back Matter
    Pages 495-510

About this book

Introduction

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Keywords

pharmacology physiology research skin

Editors and affiliations

  • Malcolm W. Greaves
    • 1
  • Sam Shuster
    • 2
  1. 1.The Institute of DermatologySt. Thomas’s HospitalLondonGreat Britain
  2. 2.Department of Dermatology, The Royal Victoria InfirmaryThe University of Newcastle upon TyneNewcastle upon TyneGreat Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-73797-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1989
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-73799-2
  • Online ISBN 978-3-642-73797-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site