Prostaglandins and Leukotrienes in Gastrointestinal Diseases

  • Wolfram Domschke
  • Hanns Gerd Dammann
  • B. M. Peskar
  • K. H. Holtermüller

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Biology and Pharmacology of Prostaglandins and Leukotrienes

    1. Front Matter
      Pages 1-1
    2. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 10-11
    3. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 20-22
    4. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 30-32
    5. F. Halter, A. Baumgartner, H. R. Koelz
      Pages 33-40
    6. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 41-43
    7. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 48-49
    8. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 55-56
  3. Protective Effects on the Gastrointestinal Mucosa. New Aspects of the Last Two Years

    1. Front Matter
      Pages 57-57
    2. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 65-65
    3. J. J. Bernier, Ch. Florent
      Pages 66-72
    4. Wolfram Domschke, Hanns Gerd Dammann, B. M. Peskar, K. H. Holtermüller
      Pages 73-74

About these proceedings

Introduction

In OCtober 1986, recognized authorities from a variety of disciplines met in Lisbon, Portugal, to review recent knowledge on eicosanoids - i. e., prostaglandins, throm­ boxane A , and leukotrienes - and their role in gastrointestinal diseases. 2 Briefly, in the stomach endogenous as well as exogenous prostaglandins may mediate cytoprotective actions in that they stimulate gastric mucus production, bicar­ bonate secretion and cellular regeneration while providing adequate mucosal blood flow. In contrast, thromboxane A2 by vasoconstriction may act as an ulcerogenic substance. Diarrheal states may be associated with prostaglandins of types E and F as they are capable to enhance intestinal water and electrolyte secretions. In chronic in­ flammatory bowel disease, mucosal synthesis of leukotrienes was found to be increased more markedly than that of prostaglandins suggesting that leukotrienes may have a major part in the pathogenesis of that disease. In this volume, which is an elaborated collection of the papers given on occasion of the above-mentioned symposium, the facts and problems associated with prostanoid substances are dealt with in four sections on 1. biochemistry, biology and pharmacology of eicosanoids, 2. physiologic and pathophysiologic aspects, 3. established therapeutic implications, and 4. treatment perspectives. We believe that the publication of these contributions by leading workers in the given fields provides a comprehensive and up-to-date appraisal of the role of eicosanoids in gastrointestinal diseases, and it is hoped that this volume will be of value to both basic scientists and practicing clinicians.

Keywords

drug gastroenterology gastrointestinal tract inflammation metabolism research

Editors and affiliations

  • Wolfram Domschke
    • 1
  • Hanns Gerd Dammann
    • 2
  • B. M. Peskar
    • 3
  • K. H. Holtermüller
    • 4
  1. 1.Medizinische Klinik mit PoliklinikUniversität Erlangen-NürnbergErlangenGermany
  2. 2.Krankenhaus BethanienHamburg 20Germany
  3. 3.Arbeitsgruppe Experimentelle Klinische MedizinRuhr-Universität BochumBochum 1Germany
  4. 4.1. Medizinische KlinikSt. Markus-KrankenhausFrankfurt/Main 50Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-73316-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-18744-8
  • Online ISBN 978-3-642-73316-1
  • About this book