Surfactant Replacement Therapy

in Neonatal and Adult Respiratory Distress Syndrome

  • Burkhard Lachmann
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XXII
  2. Pulmonary Surfactant: Evolution of Functional Concepts

  3. Experimental Evaluation of Surfactant for Replacement Therapy

    1. Front Matter
      Pages 11-11
    2. G. Enhorning
      Pages 13-17
    3. P. Gieles, T. Key, J. Van Santvoort, A. Steeghs
      Pages 18-27
    4. B. Disse, L. Gortner, E. Weller, H. Eberhardt, H. Ziegler
      Pages 37-41
    5. B. Disse, E. Weller, L. Lützen, H. Ziegler, H. Eberhardt
      Pages 42-46
  4. Diagnostics of Surfactant Deficiency

  5. Surfactant Replacement in Newborn Infants

    1. Front Matter
      Pages 89-89
    2. L. Gortner, F. Pohlandt, P. Bartmann, B. Disse, E. Weller
      Pages 134-135
    3. M. Hallman, M. Pohjavuori, K. Bry, T. A. Merritt
      Pages 136-142
    4. T. A. Merritt, M. Hallman, Y. E. Vaucher, C. Berry, A.-L. Jarvenpaa
      Pages 143-149
    5. T. A. Merritt, M. Hallman, D. Edwards
      Pages 181-188
  6. Surfactant Replacement in ARDS and Other Lung Diseases

  7. What Happens After Surfactant Replacement Therapy?

    1. Front Matter
      Pages 273-273
    2. A. Jobe, A. Pettenazzo, S. Seidner, M. Ikegami
      Pages 275-292
    3. D. S. Strayer, T. A. Merritt, R. Spragg, M. Hallman
      Pages 301-313
    4. M. P. Sherman, E. E. Aeberhard, C. T. Barrett, J. B. D’Ambola, L. A. Campbell
      Pages 314-318
  8. Prospects for the Future

    1. Front Matter
      Pages 327-327
    2. T. Curstedt, H. Jörnvall, P. Berggren, B. Robertson
      Pages 332-337
    3. S. D. Revak, T. A. Merritt, M. Hallman, C. G. Cochrane
      Pages 338-343
    4. R. Rüfer, J. Wuthe, B. Widjaja
      Pages 351-354
  9. Lipid Metabolism and Its Influence by Pharmacological Means

    1. Front Matter
      Pages 355-355

About these proceedings


I am very happy and honoured to have so many famous contrib­ utors from around the world presenting their knowledge and experience in this book, including Dr. Rufer who, as early as 1967, attempted to improve the pressure-volume curve of a child dying from RDS using dried surfactant from dogs; Drs. Enhorn­ ing and Robertson who were the first to treat rabbit fetuses with surfactant replacement and impressively demonstrated that sur­ factant improved lung mechanics; and Dr. Fujiwara who at the end of the 1970's had already successfully treated the first babies with surfactant replacement and published this work al­ ready in 1980. Thus, the idea of surfactant replacement therapy is now more or less 20 years old and almost 10 years have passed since the first publication by Dr. Fujiwara of his impressive clinical results. Up to now (September, 1988) about 2,200 babies have been treated worldwide with tracheal instillation of surfactant, with most promising results. The type of surfactant used varies from pure natural extracts from bovine or pig lungs, to surfactant extracted from human amniotic fluid, to pure phospholipids. To date, however, there is still no surfactant commercially available (except in Japan), in spite of the fact that it is urgently awaited by neonatologists and intensive care doctors throughout the world. This volume is based on the contributions presented at the international congress on Surfactant Replacement Therapy which was held in Rotterdam, The Netherlands, in November 1987.


Atmen Lipid Trauma metabolism proteins

Editors and affiliations

  • Burkhard Lachmann
    • 1
  1. 1.Department of AnesthesiologyErasmus UniversityRotterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-73307-9
  • Online ISBN 978-3-642-73305-5
  • Buy this book on publisher's site