Nephrocalcinosis Calcium Antagonists and Kidney

  • Karl-Horst Bichler
  • Walter Ludwig Strohmaier

Table of contents

  1. Front Matter
    Pages I-X
  2. Introduction

    1. Karl-Horst Bichler, Walter Ludwig Strohmaier
      Pages 1-3
  3. Fundamentals

    1. Front Matter
      Pages 5-5
    2. S. Bachmann, T. Sakai, W. Kriz
      Pages 7-33
    3. F. Lang, M. Paulmichl, P. Deetjen
      Pages 34-42
  4. Nephrocalcinosis and Calcium Antagonists

  5. Back Matter
    Pages 187-190

About this book

Introduction

The effect of calcium antagonists on heart muscle and blood circulation is the reason that they have found widespread clinical application for a number of years. Less well known, in contrast, is the effect this group of substances has on the kidneys, both on kidney cells and the blood flow through the kidneys. This effect was the subject of a workshop we organized in Tiibingen in June 1986. Different groups studied the effects of these substances, especially in animals, on the processing of calcium by the kidney cells and on blood flow. A possible explanation is that the calcium antagonists block the influx of calcium through special cell canals, especially the cells of the distal tubule. It is necessary to test whether there is a blockade or only a reduction in the passage of calcium. Our understanding of the effect of calcium antagonists is in large part based on the results of morphologic, physiologic, and pharmacologic studies of calcium in the kidneys. The particular processes involved in nephrocalcinosis are special objects of study with regard to calcium antagonists. This book presents the results of experimental studies of the effect of calcium antagonists on nephrocalcinosis and acute renal failure after ischemia. In this context, the clinician is particularly interested in the use of calcium antagonists to protect against the kidney in urolithiasis, in acute renal failure and during kidney transplantation. The book is thus of interest to urologists and nephrologists as well as pharmacologists. biochemists, physiologists, and others in research.

Keywords

calcium kidney metabolism morphology pharmacodynamics research transplantation

Editors and affiliations

  • Karl-Horst Bichler
  • Walter Ludwig Strohmaier
    • 1
  1. 1.Department of UrologyUniversity of TübingenTübingenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-72857-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-72859-4
  • Online ISBN 978-3-642-72857-0
  • About this book