Inhibitors of Cell Growth

  • Alvaro Macieira-Coelho

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 20)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Alvaro Macieira-Coelho
    Pages 1-9
  3. Rafael E. Herrera
    Pages 11-24
  4. Andrei L. Gartel, Angela L. Tyner
    Pages 43-71
  5. Douglas W. Leaman
    Pages 101-142
  6. Kjell Elgjo, Karl Ludwig Reichelt, David S. Gembitsky
    Pages 143-159
  7. James L. Kirkland, Charles H. Hollenberg
    Pages 177-195
  8. Ralf Brandt, Andreas D. Ebert
    Pages 197-248
  9. Alvaro Macieira-Coelho
    Pages 249-270
  10. Back Matter
    Pages 271-272

About this book


The containment of cell growth is at the core of the homeostatic regulation of metazoans, and considerable progress has been made in the understanding of how this is achieved. Most knowledge comes from the isolation of molecu­ les with positive and negative regulatory effects on cell proliferation, and most emphasis so far has been on these molecules. Some of these molecules are already available for therapeutic purposes, and others look promising in this respect. This volume gives examples of such approaches. The understanding of the control of cell growth is also fundamental to grasp phylogenic and ontogenic development. Why organisms have developed increasingly sophisticated mechanisms that control their size and that of their organs, how different cells originate, some destined for renewal and repair, others for specialized functions in a postmitotic state or evolving through division, others like the germinal cells waiting for the signal to start another organism. There is one mechanism of growth containment, however, about which we know very little. It concerns the structural characteristics of the cell, i.e. the relationship between structure and function. How structure can change the response to identical signals. The positive and negative growth regulators may be conserved, but the structure and organization of the genetic material and of other cell components differ widely and are responsible to a great extent for the differences in cell proliferative behaviour.


Activation Krebs RNA angiogenesis apoptosis cancer cell cell cycle cell division interferon oncogene receptor regulation replication transcription

Editors and affiliations

  • Alvaro Macieira-Coelho
    • 1
  1. 1.INSERMVersaillesFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-72151-9
  • Online ISBN 978-3-642-72149-6
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site