Presenilins and Alzheimer’s Disease

  • S. G. Younkin
  • R. E. Tanzi
  • Y. Christen
Conference proceedings

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XV
  2. P. E. Fraser, G. Yu, G. Levesque, M. Ikeda, M. Nishimura, E. Rogaeva et al.
    Pages 1-10
  3. J. Hardy, M. Hutton
    Pages 11-18
  4. R. E. Tanzi, T.-W. Kim, D. M. Kovacs, W. Wasco, R. D. Moir, W. Pettingell et al.
    Pages 19-25
  5. S. S. Sisodia, G. Thinakaran, P. C. Wong, D. R. Borchelt, M. K. Lee, A. Doan et al.
    Pages 35-47
  6. D. J. Selkoe, W. Xia, J. Zhang, M. B. Podlisny, C. A. Lemere, M. Citron et al.
    Pages 49-58
  7. W. Wasco, R. E. Tanzi, R. D. Moir, A. C. Crowley, D. E. Merriam, D. M. Romano et al.
    Pages 59-70
  8. C. Haass, J. Walter, A. Capell, C. Wild-Bode, J. Grünberg, T. Yamazaki et al.
    Pages 71-78
  9. U. Langer, C. Albrecht, M. Mayhaus, J. Velden, H. Wiegmann, J. Klaudiny et al.
    Pages 79-84
  10. H. Hartmann, J. Busciglio, B. A. Yankner
    Pages 85-91
  11. Back Matter
    Pages 99-100

About these proceedings


The discovery in 1995 that defects in the novel presenilin genes harbor defects which cause up to half of all cases of early onset familial Alzheimer's disease cases has rapidly led to the creation of a new and exciting sub-field in Alzheimer's disease research. This has clearly been evidenced by the fact that over 250 papers have now been published regarding the presenilins since their identification in 1995. One of the earliest findings regarding the role of the presenilins in Alzheimer's disease was the discovery that like familial Alzheimer's disease mutations in the amyloid ß protein precursor gene, those in the presenilins lead to dramatically increased production of ß-amyloid in the brains of AD patients. Additionally, the presenilins appear to play roles in programmed cell death (apoptosis) and in CNS development. The provocative chapters in this book written by some of the most highly respected experts in the area of Alzheimer's disease research present some of the latest information concerning the biological function of the presenilins and how defects in these genes cause Alzheimer's disease. The knowledge contained in this volume should help to accelerate ongoing attempts to develop novel treatments for Alzheimer's disease and related disorders.


Alzheimer's disease Alzheimer´s disease activation biology brain cell cell death dementia genetics metabolism molecular genetics mutation programmed cell death regulation transcription

Editors and affiliations

  • S. G. Younkin
    • 1
  • R. E. Tanzi
    • 2
  • Y. Christen
    • 3
  1. 1.Mayo Clinic JacksonvilleJacksonvilleUSA
  2. 2.Genetics and Aging Unit and the Department of NeurologyMassachusetts General Hospital-East Harvard Medical SchoolBostonUSA
  3. 3.Fondation IPSENParis Cedex 16France

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-72105-2
  • Online ISBN 978-3-642-72103-8
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site