Somatic Diversification of Immune Responses

  • Garnett Kelsoe
  • Martin F. Flajnik

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 229)

Table of contents

  1. Front Matter
    Pages I-IX
  2. D. B. Winter, N. Sattar, P. J. Gearhart
    Pages 1-10
  3. U. Storb, A. Peters, E. Klotz, N. Kim, H. M. Shen, K. Kage et al.
    Pages 11-19
  4. R. V. Blanden, H. S. Rothenfluth, E. J. Steele
    Pages 21-32
  5. D. M. Tarlinton, A. Light, G. J. V. Nossal, K. G. C. Smith
    Pages 71-83
  6. J. Przylepa, C. Himes, G. Kelsoe
    Pages 85-104
  7. L. J. Wysocki, A. H. Liu, P. K. Jena
    Pages 105-131
  8. T. B. Kepler, S. Bartl
    Pages 149-162
  9. L. Du Pasquier, M. Wilson, A. S. Greenberg, M. F. Flajnik
    Pages 199-216
  10. Back Matter
    Pages 217-225

About this book


Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo­ ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re­ markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec­ tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.


Antigen Antikörper antibody cell development evolution gene genetics immune response immunity immunoglobulin immunology lymphocytes mutation transcription

Editors and affiliations

  • Garnett Kelsoe
    • 1
  • Martin F. Flajnik
    • 2
  1. 1.Department of Microbiology and ImmunologyUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Miami School of MedicineMiamiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71986-8
  • Online ISBN 978-3-642-71984-4
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site