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Radioimmunoassay in Basic and Clinical Pharmacology

  • Carlo Patrono
  • Bernhard A. Peskar

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 82)

Table of contents

  1. Front Matter
    Pages I-XXII
  2. J. Grassi, J. Maclouf, P. Pradelles
    Pages 91-141
  3. E. Ezan, S. Mamas, C. Rougeot, F. Dray
    Pages 143-179
  4. D. Rodbard, V. Guardabasso, P. J. Munson
    Pages 193-212
  5. C. Patrono
    Pages 213-225
  6. F. Nyberg, I. Christensson-Nylander, L. Terenius
    Pages 227-253
  7. J. H. Walsh, H. C. Wong
    Pages 315-350
  8. M. L. Michener, D. Schwartz, M. G. Currie, D. M. Geller, P. Needleman
    Pages 351-362
  9. M. Pazzagli, M. Serio
    Pages 363-400
  10. L. Bartalena, S. Mariotti, A. Pinchera
    Pages 401-431
  11. E. Knoll, H. Wisser
    Pages 433-448
  12. H. J. Zweerink, G. A. Limjuco, E. C. Hayes
    Pages 481-500
  13. C. W. Parker
    Pages 501-515
  14. D. S. Pepper
    Pages 517-541
  15. L. E. Underwood, M. G. Murphy
    Pages 561-574
  16. Back Matter
    Pages 591-611

About this book

Introduction

Thirty years have elapsed since the first description by S. A. BERSON and R. S. Y ALOW of the basic principles of radioimmunoassay (RIA). During this period of time, RIA methodology has been instrumental to the growth of many areas of biomedical research, including endocrinology, oncology, hematology, and pharmacology. It has done so by providing a relatively simple universal tool allowing, for the first time, the detection of endogenous mediators that are present 12 10 in body fluids at concentrations as low as 10- _10- M. The fundamental nature of this discovery and the wide-ranging fall-out of basic and clinical knowledge derived from its application have been acknowledged by the many honors tributed to its pioneers, including the Nobel Prize awarded to Dr. Y ALOW 10 years ago. Although several excellent books have been published during the past decades covering various aspects of RIA methodology, we felt the need, as pharmacologists, for a comprehensive discussion of the methodological and conceptual issues related to the main classes of mediators of drug action and to drugs themselves. Thus, we gladly accepted the challenge provided by the invitation to edit a volume of the Handbook of Experimental Pharmacology on Radioimmunoassay in Basic and Clinical Pharmacology. We tried to balance the emphasis placed on more general aspects of the RIA methodology and that on specific mediators.

Keywords

drug endocrinology pharmacology research

Editors and affiliations

  • Carlo Patrono
    • 1
  • Bernhard A. Peskar
    • 2
  1. 1.Institute of PharmacologyCatholic University of the Sacred HeartRomeItaly
  2. 2.Institute of Pharmacology and ToxicologyRuhr-University Bochum Im LottentalBochum 1Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71809-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71811-3
  • Online ISBN 978-3-642-71809-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site