Systemic Lupus Erythematosus

Clinical and Experimental Aspects

  • Josef S. Smolen
  • Christoph C. Zielinski

Table of contents

  1. Front Matter
    Pages I-XIV
  2. General Considerations

    1. Front Matter
      Pages 1-1
    2. W. Graninger, J. S. Smolen, C. C. Zielinski
      Pages 2-5
  3. Animal Models of Systemic Lupus Erythematosus: Genetic, Viral and Immunologic Aspects

    1. Front Matter
      Pages 21-21
    2. M. F. Seldin, J. D. Mountz, A. D. Steinberg
      Pages 22-49
    3. T. M. Chused, K. L. McCoy, R. B. Lal, Th. R. Malek, E. M. Brown, L. J. Edison et al.
      Pages 50-59
  4. Immunologic and Genetic Aspects of Human SLE

    1. Front Matter
      Pages 87-87
    2. D. Isenberg, Y. Shoenfeld, R. S. Schwartz
      Pages 88-104
    3. M. Reichlin, J. B. Harley
      Pages 105-123
    4. G. Tappeiner
      Pages 124-144
  5. Clinical Aspects of Human SLE

    1. Front Matter
      Pages 169-169
    2. W. Ulrich, G. Syré
      Pages 204-226
    3. T. A. Luger, D. Benesch
      Pages 227-250
    4. E. Maida, E. Horvatits
      Pages 251-269
    5. G. Seidl
      Pages 270-289
    6. J. S. Smolen, A. D. Steinberg, T. M. Chused
      Pages 290-297
  6. Therapeutic Aspects of SLE

  7. Back Matter
    Pages 355-358

About this book


More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re­ cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes­ tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in­ crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub­ lished at a time of renewed interest in SLE, elicited by the descrip­ tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac­ terized by an abnormal immune response, although its pathogenetic implications were still unclear.


antibody attention autoimmune disease autoimmunity dermatology immune response immunity organ pathogenesis pathology skin systemic lupus erythematosus

Authors and affiliations

  • Josef S. Smolen
    • 1
  • Christoph C. Zielinski
    • 1
  1. 1.Allgemeines Krankenhaus der Stadt WienII. Medizinische UniversitätsklinikWienAustria

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71644-7
  • Online ISBN 978-3-642-71642-3
  • Buy this book on publisher's site