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Table of contents

  1. Front Matter
    Pages i-vii
  2. W. Trager, M. E. Perkins, H. N. Lanners
    Pages 57-70
  3. Abraham Rubinstein, Joseph R. Robinson
    Pages 71-107
  4. A. Hubbuch, E. Debus, R. Linke, W. J. Schrenk
    Pages 109-143
  5. Back Matter
    Pages 145-148

About these proceedings

Introduction

Malaria is a disease of long duration and chronicity. Typical infections with Plas­ modium vivax or P. ovale last 2 to 3 years, with periodic remissions and relapses. P. malariae may persist as a latent inapparent infection up to 50 years. Even with P. Jalciparum, the most highly pathogenic species of human malaria, immunity de­ velops only slowly l). Under natural conditions in a holoendemic region where expo­ sure to reinfection is frequent and sustained, children that survive their initial infec­ tions show an enlarged spleen and are likely to continue to show parasites until puber­ ty, or even beyond. In such a region adults do not have a markedly enlarged spleen, rarely show parasites and are rarely ill with malaria. This acquired immunity is effec­ tive mainly against the local strains of falciparum malaria and fades rapidly if the individual lives for some months in a non-malarious region. Nevertheless, if such an immunity could be induced earlier by vaccination, and especially if it could be induced in young children, many lives would be saved and much illness prevented. An effective vaccine would also serve as an additional tool which, combined with mosquito control measures and appropriate chemotherapy, might greatly reduce the incidence of malaria. Clearly a vaccine could also be useful for the protection of short term visitors to malarious regions. Such protection is becoming increasingly difficult to provide as drugresistant strains of P. Jalciparum continue to spread 2).

Keywords

chemotherapy drug drug delivery infection infections malaria parasite vaccine

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-71502-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71504-4
  • Online ISBN 978-3-642-71502-0
  • Series Print ISSN 0177-8757
  • Buy this book on publisher's site