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Organotitanium Reagents in Organic Synthesis

  • Manfred T. Reetz
Book

Part of the Reactivity and Structure: Concepts in Organic Chemistry book series (REACTIVITY, volume 24)

Table of contents

  1. Front Matter
    Pages I-X
  2. Manfred T. Reetz
    Pages 1-16
  3. Manfred T. Reetz
    Pages 113-122
  4. Manfred T. Reetz
    Pages 194-198
  5. Manfred T. Reetz
    Pages 199-222
  6. Manfred T. Reetz
    Pages 223-229
  7. Back Matter
    Pages 231-236

About this book

Introduction

Titanium has been used to perform many kinds of reactions in organic and inorganic chemistry. The present book is concerned primarily with a new development in titanium chemistry which is useful in organic synthesis. In 1979/80 it was discovered that the titanation of classical carbanions using C1TiX leads to species with reduced basicity and reactivity. This increases 3 chemo-, regio-and stereo selectivity in reactions with organic compounds such as aldehydes, ketones and alkyl halides. Many new examples have been reported in recent times. Since the nature of the ligand X at titanium can be widely varied, the electronic and steric nature of the reagents is easily controlled. This helps in predicting the stereochemical outcome of many of the C-C bond forming reactions, but the trial and error method is still necessary in other cases. One of the ultimate objectives of chemistry is to understand correlations between structure and reactivity. Although this goal has not been reached in the area of organotitanium chemistry, appreciable progress has been made. A great deal of physical and computational data of organotitanium compounds described in the current and older literature (e. g. , Ziegler-Natta type catalysts) has been reported by polymer, inorganic and theoretical chemists. It is summarized in Chapter 2 of this book, because some aspects are useful in understanding reactivity and selectivity of organo­ titanium compounds in organic synthesis as described in the chapters which follow.

Keywords

chirality organic chemistry organic synthesis polymer synthesis

Authors and affiliations

  • Manfred T. Reetz
    • 1
  1. 1.Fachbereich Chemie der Universität MarburgMarburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-70704-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-70706-3
  • Online ISBN 978-3-642-70704-9
  • Series Print ISSN 0341-2377
  • Buy this book on publisher's site