Fundamentals of Immunology

  • Otto G. Bier
  • Wilmar Dias Da Silva
  • Dietrich Götze
  • Ivan Mota

Table of contents

  1. Front Matter
    Pages I-X
  2. Ivan Mota
    Pages 35-62
  3. Ivan Mota
    Pages 63-72
  4. Otto G. Bier
    Pages 73-114
  5. Wilmar Dias Da Silva
    Pages 115-138
  6. Dietrich Götze, Reinhard Burger
    Pages 139-178
  7. Otto G. Bier
    Pages 179-226
  8. Otto G. Bier
    Pages 227-242
  9. Ivan Mota
    Pages 243-296
  10. Dietrich Götze, Ivan Mota
    Pages 297-316
  11. Dietrich Götze, Wilmar Dias da Silva
    Pages 317-358
  12. Wilmar Dias Da Silva, Dietrich Götze
    Pages 359-382
  13. Wilmar Dias Da Silva, Dietrich Götze
    Pages 383-413
  14. Wilmar Dias Da Silva
    Pages 415-437
  15. Back Matter
    Pages 439-469

About this book


The good acceptance of this textbook is an indication that it has served its purpose. The present edition has been prepared in order to cover the main progress achieved in the five years that have elapsed since the first edition. The structure of the book remains essentially the same but a con­ siderable amount of new material has been introduced, particularly in certain areas such as the genetics of immunoglobulins and T cell receptor, the regulation of the immune response, hypersensitivity reactions, and cellular immunology. Today, immunology is essential for biologists in general and in particular for physicians, veterinarians, and pathologists. The great progress and diversification that has taken place in the last few years is due to its enormous value both for the understanding of theoretical biology and for the practical resolution of biochemical, genetic, pathological, and biological problems. Greatly contributing to this progress have been relatively sophisticated techniques, such as immunofluorescence, radioimmune assay, transmission electron micro­ scopy, scanning electron microscopy, isoelectric focusing, quantitative cytofluorimetry, affinity chromatography, and techniques that allow separation of the different lymphocyte subpopulations. A potentially fabulous field was recently opened with the development of techniques for obtaining monoclonal antibodies by fusion of immunologically active lymphocytes with myeloma cells. These hybrid cells produce large amounts of monoclonal antibodies or other lymphocyte factors. The establishment of this hybridoma technology, that is already routine in most laboratories, is being used in the resolution of general biology problems, particularly in the study of the various cell surface molecules.


Antigen T cell autoimmunity blood genetics histocompatibility immunoglobulin immunomodulation lymphocytes transplantation

Authors and affiliations

  • Otto G. Bier
    • 1
  • Wilmar Dias Da Silva
    • 2
  • Dietrich Götze
    • 3
    • 4
    • 5
  • Ivan Mota
    • 6
  1. 1.Laboratório Especial de Imunologia AplicadaInstituto ButantanSão PauloBrazil
  2. 2.Instituto de Bioĉiencias, Departamento de Microbiologia e ImunologiaCidade UniversitáriaSão PauloBrazil
  3. 3.University Medical SchoolHeidelbergGermany
  4. 4.The Wistar InstitutePhiladelphiaUSA
  5. 5.The University of PennsylvaniaPhiladelphiaUSA
  6. 6.Centro de Imunologia da OMS/OPSInstituto ButantanSão PauloBrazil

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1986
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-15332-0
  • Online ISBN 978-3-642-70393-5
  • Buy this book on publisher's site