The Pathogenesis of Bacterial Infections

  • George Gee Jackson
  • Herbert Thomas
Conference proceedings

Part of the Bayer-Symposium book series (BAYER-SYMP, volume 8)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Welcome

    1. H. Thomas
      Pages 1-2
  3. Introduction

    1. G. G. Jackson
      Pages 3-5
  4. Infection of Mucosal Surfaces

    1. Front Matter
      Pages 7-7
    2. P. W. Anderson, Th. Inzana, M. Pichichero
      Pages 30-40
    3. G. K. Schoolnik, J. B. Rothbard
      Pages 41-50
    4. D. C. Morrison, S. W. Vukajlovich, S. A. Goodman, H.-W. Wollenweber
      Pages 68-84
    5. J. R. McGhee, S. M. Michalek, H. Kiyono, S. I. Williamson, T. A. Brown, J. Mestecky
      Pages 85-99
  5. Extension of Infection Beyond the Surface Cells — Circumvention of the Host Defense System

  6. Features of Bacterial Virulence

    1. Front Matter
      Pages 167-167
    2. V. Braun
      Pages 168-176
    3. D. W. Dyer, S. E. H. West, P. F. Sparling
      Pages 177-192
    4. T. Wadström, L. Switalski, P. Speziale, K. Rubin, C. Rydén, G. Fröman et al.
      Pages 193-207
    5. Th. F. Meyer, R. Haas, R. Halter, P. Nickel, J. Pohlner, A. Stern et al.
      Pages 221-234
    6. B. H. Iglewski, T. I. Nicas
      Pages 257-267
    7. S. Bhakdi, W. Seeger, N. Suttorp, J. Tranum-Jensen
      Pages 268-280
  7. Tissue Invasion, Inflammation, and Immunpathologic Disease

  8. Concluding Remarks to Sessions 1–4

    1. Front Matter
      Pages 367-367
    2. W. Opferkuch
      Pages 372-374
    3. V. Braun
      Pages 375-376
  9. Research Perspectives

    1. Front Matter
      Pages 385-386
    2. Methods for Research on Bacterial Pathogenesis

      1. E. N. Robinson Jr., Z. A. McGee, M. E. Hammond, J. T. Poolman, Th. M. Buchanan, G. K. Schoolnik et al.
        Pages 387-391
      2. R. L. Duncan Jr., D. C. Morrison
        Pages 392-397
      3. J. W. Costerton
        Pages 399-400
    3. Specific Microbial Adaptation in Pathogenesis

    4. Host Tissue and Parasite Interactions in Bacterial Pathogenesis

About these proceedings


G. G. Jackson The pathogenesis of bacterial infection defines the dynamics at an interface of ecologic association of bacteria and host. First, it occurs at the portal of initial contact with a per­ missive target cell. The infected cell provides either a passive or a specific receptor for the bacterium or its products, to­ gether with ligands and an environment of helper and inhibiting factors. The result is bacterial replication to produce an im­ balance of a potentially commensal relation which, under other defined conditions, would be optimal for the survival of both the host and bacterial cells. Virulence and pathogenesis are both absolute and relative terms. They must be interpreted strictly according to the circumstances of site-specific inter­ actions of bacterial and host cells, membrane composition, structure, characteristics, and environmental substances. The bacteria themselves may have, acquire, or switch on or off under certain conditions, the products or properties that produce cellular damage that we recognize as virulence. Another result of bacterial infection may be to stimulate a normal host cell function to perform at a pathophysiologic level, causing illness that we recognize as virulence. A third marker of virulence may be the ability to invade a cell or tissue barrier and produce a pathologic effect at a site that is remote from the portal of commensal association or pathologic entry.


Infections antibiotic antibody antigen bacterial infection bacterial infections cell dynamics gene immune system infection parasite pathogenesis tissue vaccine

Editors and affiliations

  • George Gee Jackson
    • 1
  • Herbert Thomas
    • 2
  1. 1.Department of Medicine, Section of Infectious DiseasesThe University of Illinois at Chicago College of MedicineChicagoUSA
  2. 2.Bayer AG, Pharma-ForschungszentrumInstitut für ChemotherapieWuppertal 1Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-70353-9
  • Online ISBN 978-3-642-70351-5
  • Series Print ISSN 0067-4672
  • Buy this book on publisher's site