© 1985

The Tetracyclines

  • J. J. Hlavka
  • J. H. Boothe

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 78)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. J. H. Boothe, J. J. Hlavka
    Pages 1-3
  3. Z. Hošťálek, Z. Vaněk
    Pages 137-178
  4. W. Rogalski
    Pages 179-316
  5. B. A. Cunha
    Pages 393-404
  6. R. H. Gustafson, J. S. Kiser
    Pages 405-446
  7. Back Matter
    Pages 447-451

About this book


The history of antibiotics may weIl have begun with the ancient Sudanese-Nubian civilization (see Chapter 1, "Historical Introduction"), but this volume reflects a more contemporary appraisal of the antibiotic era. We have compiled a comprehensive review of the tetracyclines which includes all the major sub­ divisions of these chemically important and clinically useful antibiotics. There can be little doubt about the contribution of antibiotics to both the increase in human life span and the alleviation of much human suffering. The tetracyclines are still playing an important role in these areas and will continue to do so in the foreseeable future. We hope this volume will be an important contribution to a better under­ standing of the chemistry, biochemistry, and medical aspects of tetracycline antibiotics. We are indebted to the individual authors who have given so much of their time and effort in the preparation of the chapters. Pearl River, NY J OSEPH J. HLA VKA Ocean Gate, NJ JAMES H. BOOTHE Contents CHAPTER 1 Historical Introduction. J. H. BOOTHE and J. J. HLAVKA References. 3 CHAPTER 2 Fermentation and Mutational Development of the Tetracyclines J. J. GOODMAN A. Introduction 5 B. The Producing Microorganisms . 6 I. Morphology and Ultrastructure 6 11. Mutation and Strain Selection 8 111. Cosynthesis. 13 The Fermentation Process 14 C. I. Inoculum 14 11. Contamination 16 Complex Media. 18 111. IV. Synthetic Media. 27 V. Stimulators and Inhibitors 30 Directed Fermentations 32 VI.


antibiotics biochemistry chemistry

Editors and affiliations

  • J. J. Hlavka
    • 1
  • J. H. Boothe
    • 2
  1. 1.Medical Research Division, Lederle LaboratoriesAmerican Cyanamid CompanyUSA
  2. 2.Ocean GateUSA

Bibliographic information

  • Book Title The Tetracyclines
  • Editors Joseph J. Hlavka
    James H. Boothe
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-15259-0
  • Softcover ISBN 978-3-642-70306-5
  • eBook ISBN 978-3-642-70304-1
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XIV, 454
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site