Advertisement

Human T-Cell Leukemia Virus

  • Peter K. Vogt

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 115)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Marjorie Robert-Guroff, Philip D. Markham, Mikulas Popovic, Robert C. Gallo
    Pages 7-31
  3. Kazuo Tajima, Suketami Tominaga
    Pages 53-66
  4. William A. Blattner, Robert C. Gallo
    Pages 67-88
  5. Kiyoshi Takatsuki, Kazunari Yamaguchi, Fumio Kawano, Hiromichi Nishimura, Motoharu Seiki, Mitsuaki Yoshida
    Pages 89-97
  6. Mitsuaki Yoshida, Seisuke Hattori, Motoharu Seiki
    Pages 157-175
  7. William A. Haseltine, Joseph G. Sodroski, Roberto Patarca
    Pages 177-209
  8. Robin A. Weiss, Paul Clapham, Karoly Nagy, Hiroo Hoshino
    Pages 235-246
  9. Thomas J. Palker, Dani P. Bolognesi, Barton F. Haynes
    Pages 247-266

About this book

Introduction

characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re­ verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar­ ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids.

Keywords

cell gene leukemia protein proteins retroviruses tumor virus

Editors and affiliations

  • Peter K. Vogt
    • 1
  1. 1.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-70113-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1985
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-70115-3
  • Online ISBN 978-3-642-70113-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site