Sleep, Benzodiazepines and Performance

Experimental Methodologies and Research Prospects

  • Ian Hindmarch
  • Helmut Ott
  • Tom Roth
Conference proceedings

Part of the Psychopharmacology Supplementum book series (PSYCHOPHARM, volume 1)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Sleep and Insomnia

    1. Front Matter
      Pages 1-1
    2. F. Zorick, N. Kribbs, T. Roehrs, T. Roth
      Pages 2-10
    3. W. Dement, W. Seidel, M. Carskadon
      Pages 11-43
  3. Effects of Hypnotics in Insomniacs

  4. Pharmacokinetics and Pharmacodynamics of Benzodiazepines

  5. Differential Effects of Benzodiazepines

  6. Résumé

    1. Front Matter
      Pages 193-193
  7. Back Matter
    Pages 203-226

About these proceedings


The following papers were presented at an International Workshop on experi­ mental methodologies and research strategies in sleep, benzodiazepines and per­ formance during the VII. International Congress of Psychiatry in Vienna 1983. Authors were asked to examine and review the methods used and the results obtained from the various studies within their particular expertise and to provide guidelines for future strategies in the psychopharmacology of sleep. It has long been felt by sleep researchers, psychopharmacologists and clini­ cians that the effects of drugs on sleep or even sleep itself cannot be evaluated without reference to the daytime behaviour of the individual. Sleep and daytime performance are complementary aspects of the same circadian cycle. The modifi­ cation of sleep parameters by hypnotic medication must necessarily have an impact upon daytime behaviour. The overall change in a patient's daytime behaviour following nocturnal administration of a benzodiazepine is of importance when considering the toler­ ability and safety of the drug in clinical use. Alterations to the integrity of daytime performance also have consequences for that patient's subsequent sleep and nocturnal behaviour. Thus this workshop was conceived as a platform for examining the inter­ relationship of sleep, benzodiazepine hypnotics and daytime performance from pharmacological, psychological, experimental and clinical standpoints. The fol­ lowing papers also highlight the complexity of the interaction between sleep, patient, drug and daytime performance and emphasize the need to approach problem areas with appropriate research strategies and experimental method­ ologies.


Benzodiazepine Schlafstörung Sleep drug pharmacology psychiatry psychopharmacology research

Editors and affiliations

  • Ian Hindmarch
    • 1
  • Helmut Ott
    • 2
  • Tom Roth
    • 3
  1. 1.Human Psychopharmacology Research UnitUniversity of LeedsGB-LeedsUK
  2. 2.Research Laboratories, Section Electrophysiology/PsychometricsSchering AGBerlin 65Germany
  3. 3.Sleep Disorders and Research CenterHenry Ford HospitalDetroitUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69661-9
  • Online ISBN 978-3-642-69659-6
  • Series Print ISSN 0931-6795
  • Buy this book on publisher's site