The Molecular Biology of Adenoviruses 1

30 Years of Adenovirus Research 1953–1983

  • Walter Doerfler

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 109)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Lennart Philipson
    Pages 1-52
  3. Fuyuhiko Tamanoi, Bruce W. Stillman
    Pages 75-87
  4. Ulf Pettersson, Anders Virtanen, Michel Perricaudet, Göran Akusjärvi
    Pages 107-123
  5. Roberto Weinmann, Steven Ackerman, David Bunick, Michael Concino, Ruben Zandomeni
    Pages 125-145
  6. William D. Richardson, Heiner Westphal
    Pages 147-165
  7. W. Doerfler, R. Gahlmann, S. Stabel, R. Deuring, U. Lichtenberg, M. Schulz et al.
    Pages 193-228
  8. Back Matter
    Pages 229-234

About this book

Introduction

A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo­ lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu­ dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans­ formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea­ lized in the late 1960s and the 1970s.

Keywords

DNA biology cell genetics molecular biology virology virus

Editors and affiliations

  • Walter Doerfler
    • 1
  1. 1.Institut für GenetikUniversität zu KölnKöln 41Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69460-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69462-2
  • Online ISBN 978-3-642-69460-8
  • Series Print ISSN 0070-217X
  • About this book