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Antimalarial Drugs I

Biological Background, Experimental Methods, and Drug Resistance

  • Wallace Peters
  • William H. G. Richards

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 68 / 1)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. The Malaria Parasites

    1. Front Matter
      Pages 1-1
    2. P. C. C. Garnham
      Pages 3-30
    3. I. W. Sherman
      Pages 31-81
    4. W. H. G. Richards
      Pages 83-98
  3. Host Responses to Malaria

    1. Front Matter
      Pages 99-99
    2. G. H. Mitchell
      Pages 101-125
    3. V. Boonpucknavig, T. Srichaikul, S. Punyagupta
      Pages 127-176
  4. Experimental Models

    1. Front Matter
      Pages 177-177
    2. W. H. G. Richards
      Pages 207-224
    3. A. L. Ager Jr.
      Pages 225-264
    4. R. N. Rossan
      Pages 265-280
    5. S.-C. Chou, K. A. Conklin, M. R. Levy, D. C. Warhurst
      Pages 281-329
    6. G. A. T. Targett
      Pages 331-348
  5. Preclinical and Clinical Trial Techniques

    1. Front Matter
      Pages 349-349
    2. M. H. Heiffer, D. E. Davidson Jr., D. W. Korte Jr.
      Pages 351-373
    3. M. Fernex
      Pages 375-397
  6. Antimalarial Drug Resistance

    1. Front Matter
      Pages 421-421
    2. K. H. Rieckmann
      Pages 447-460
  7. Back Matter
    Pages 475-486

About this book

Introduction

Of all the parasitic diseases that beset man in the warmer parts of the world, malaria is still the major cause of morbidity and mortality. In spite of intensive efforts to interrrupt its transmission malaria still threatens over 800 million people, more than one-fifth of the world's population. Malignant tertian malaria caused by Plasmodium Jalciparum probably kills a million every year. Vivax malaria temporarily incapacitates millions more. The search for antimalarial drugs, both natural and syn. thetic, has been and continues to be one of the most challenging and, at times, rewarding exercises ever undertaken by ;:;hemists and biologists. The magnitude of the effort is reflected by the fact that, in the last 15 years, well over 250000 compounds have been screened for antimalarial activity in just one programme, that carried out under the auspices of the Walter Reed Army Institute of Research, not to mention sporadic studies undertaken by other research workers and organisations. While most people engaged in the search for new drugs agree that a rational approach based on knowledge of the intimate biochemical pathways of the target cells would be ideal as well as intellectually satisfying, most are reluctantly obliged to concede that, up to the present time, the chances of success following a more or less empirical search have been far greater. Spectacular advances in molecular biology and biochemistry in recent years, however, are rapidly changing this situation.

Keywords

Drogen Malaria antigen biochemistry biology chemistry chemotherapy clinical trial drug research metabolism parasite pharmacodynamics pharmacokinetics research vaccine

Editors and affiliations

  • Wallace Peters
    • 1
  • William H. G. Richards
    • 2
  1. 1.London School of Hygiene and Tropical MedicineLondonGreat Britain
  2. 2.Scientific Advisory ServicesWellcome Research LaboratoriesBerkhamsted, Herts.Great Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69251-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69253-6
  • Online ISBN 978-3-642-69251-2
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site