Modes and Mechanisms of Microbial Growth Inhibitors

  • Fred E. Hahn

Part of the Antibiotics book series (ANTIBIOTICS, volume 6)

Table of contents

  1. Front Matter
    Pages I-X
  2. C. H. Hassall
    Pages 1-11
  3. W. A. Creasey
    Pages 12-33
  4. F. E. Hahn
    Pages 34-45
  5. H. Wolf, E. Fischer
    Pages 71-89
  6. J. R. Knowles
    Pages 90-107
  7. A. D. Wolfe
    Pages 108-120
  8. D. I. Edwards
    Pages 121-135
  9. N. Tanaka
    Pages 136-152
  10. E. Cadman
    Pages 153-160
  11. P. G. Canonico
    Pages 161-186
  12. F. Reusser
    Pages 187-198
  13. M. S. Wysor
    Pages 199-232
  14. K. Komiyama, I. Umezawa
    Pages 233-237
  15. J. Jonák, I. Rychlík
    Pages 238-247
  16. A. Jiménez, D. Vázquez
    Pages 248-254
  17. J. S. Tkacz
    Pages 255-278
  18. L. Carrasco, D. Vázquez
    Pages 279-295
  19. Back Matter
    Pages 333-343

About this book


It is not certain that the editors of Antibiotics I (1967), Drs. GOTTLffiB and SHAW, fully realized that they were laying the foundation for an entire series of which we present here Vol. VI. For some time to come, this will be the last volume of the Antibiotics series. There are several reasons for this. Firstly, the discovery of medicinally useful antibiotics has leveled off, because the number of microbiological products with antimicrobial properties is not infinite. In 1972 some 2500 antibiotic substances were known, of which approximately one per cent are clinically useful. Further search for antibiotics has led to increasing frequency of rediscoveries and drasti­ cally decreasing frequency of discoveries of new antibiotics. As the search for antibiotics with a standard methodology in conventional ecological niches has exhausted itself, there is a paucity of new and interesting substances on which to undertake modes/mechanisms of action studies. Secondly, the mechanism of action field has come of age and its results are now academic knowledge. This also holds true for synthetic chemothera­ peutic drugs and becomes the case rapidly for toxic substances with anti-eukar­ yotic action. The study of mechanisms of action was undertaken for two reasons: one was the basic scientific desire to know how antimicrobial substances inter­ fered with microbial biochemistry; the second one was the hope that such infor­ mation would be useful in the premeditated design of synthetic antimicrobials.


Wachstumshemmung antimicrobials biochemistry biological chemistry growth

Editors and affiliations

  • Fred E. Hahn
    • 1
  1. 1.Division of Communicable Diseases and ImmunologyWalter Reed Army Institute of ResearchUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68948-2
  • Online ISBN 978-3-642-68946-8
  • Buy this book on publisher's site