Advertisement

New Toxicology for Old

A Critique of Accepted Requirements and Methodology

  • Claire M. Chambers
  • Philip L. Chambers
Conference proceedings

Part of the Archives of Toxicology book series (TOXICOLOGY, volume 5)

Table of contents

  1. Front Matter
    Pages I-X
  2. Young Scientists Award Lecture 1981: The Identification of an Accumulation System for Diamines and Polyamines Into the Lung and Its Relevance to Paraquat Toxicity

  3. Critical Evaluation of Protocols Used in Routine Toxicity Studies

  4. Neurotoxicology

    1. Front Matter
      Pages 69-69
    2. G. Winneke, H. Lilienthal, W. Werner
      Pages 84-93
    3. K. Savolainen, V. Riihimäki, A. Laine, J. Kekoni
      Pages 96-99
    4. Anna Maria Seppäläinen, H. Savolainen
      Pages 100-102
    5. E. Malizia, S. Borgo, C. Carapella, V. Chiavarelli, A. Russo, V. Gagliardi et al.
      Pages 103-104
    6. A. Mutti, A. Cavatorta, G. Lommi, S. Lotta, I. Franchini
      Pages 120-124
    7. K. Thuránszky, I. Kiss, Margit Botos, A. Szebeni
      Pages 125-128
    8. H. Ronneberger, F. Blackkolb, G. Guthöhrlein
      Pages 129-132
  5. Non-Invasive and Invasive Techniques in Toxicology

  6. Drugs in Obstetrics and Gynaecology

    1. Front Matter
      Pages 193-193
    2. P. J. Lewis
      Pages 195-196
    3. P. Scorza Barcellona, A. Campana, B. Silvestrini, C. De Martino
      Pages 197-201
    4. R. B. Carrington da Costa, E. R. Maul, J. Pimentel, J. S. Gonçalves, A. Rebelo, L. C. Oliveira et al.
      Pages 202-204
    5. D. M. Pugh, H. S. Sumano
      Pages 209-213
    6. E. Sabbioni, C. Gregotti, J. Edel, E. Marafante, A. Di Nucci, L. Manzo
      Pages 225-230
  7. Statistics in Toxicology

About these proceedings

Introduction

Nervous system is in the most cases a likely target for the untoward effects of chemicals. The harmful consequences affect primarily the individual but may also considerably strain the whole society. The consumption of ethanol is a glaring example (National Institute on Alcohol Abuse and Alcoholism 1978). As ethanol, many organic liquids have similar immediate effects on the nervous system. The rapidity of the response suggests the involvement of the neuronal communication. The nervous system is also vulnerable to the depletion of oxygen, another common cause for the rapid deterioration of the brain function. It is quite impossible to list all the effects produced by the very large number of the individual chemicals. It would be more fruitful to try to understand the characteristics of the nervous system and the biochemical toxic mechanisms in the evaluation of the neurotoxicity of chemicals. Transfer of Xenobiotics in the Brain The adult central nervous system displays a functional barrier toward the blood-borne chemicals so that water-soluble compounds with an approximate molecular weight above 100 are largely prevented from directly entering the brain (Bradbury 1979). The functional barrier has morphological features typical to it and has a very close association of adjacent capillary cells separated by clefts of 12 A wide (Jacobs 1978). The nervous system capillaries are enveloped by glial cell tongues, and these pericytes contain contractile elements (Le Beux and Willemot 1978a, b) so that the capillaries can be constricted.

Keywords

Antigen Drogen Thymus Toxicology neurotoxicity neurotoxicology pesticide

Editors and affiliations

  • Claire M. Chambers
    • 1
  • Philip L. Chambers
    • 1
  1. 1.Department of Pharmacology, Trinity CollegeUniversity of DublinDublin 2Ireland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68511-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-11406-2
  • Online ISBN 978-3-642-68511-8
  • Series Print ISSN 0171-9750
  • Buy this book on publisher's site