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Central Cardiovascular Control

Basic and Clinical Aspects

  • Detlev Ganten
  • Donald Pfaff
Conference proceedings

Part of the Current Topics in Neuroendocrinology book series (CT NEUROENDOCRI, volume 3)

About these proceedings

Introduction

The most prominent function of the central nervous system is the control of motor functions by rapidly transmitted impulses through efferent cranial and spinal peripheral nerves. Besides electrically transmitted neural impulses, humoral mechanisms with more sustained actions are exercised by the brain and spinal cord to regulate body homeostasis. Thus, the brain may be regarded as an "endocrine gland" discharging neurohormones (peptides) either into the general circulation (neurohypophyseal hormones) or into the hypothalamo-adenohypophyseal portal circulation (releasing and inhibiting hormones). The brain, therefore, which is protected by the blood-brain barrier from disturbing and potentially noxious exogenous and endogenous agents circulating in the blood, has to have certain neurohemal regions beyond this barrier, such as the neural lobe and the median eminence (infundibulum), where neurohor­ mones have free access to the blood stream. To regulate somatic and autonomic functions in the best possible way, the central nervous system is highly dependent on feedback signals conveyed through somatic and visceral afferent nerves as well as on peripheral humoral signals such as peripheral hormones and other circulating substances that are under homeostatic regulation, e. g. , peptides, arnines, electrolytes, and other biologically active agents. In this chapter, the role of the blood-brain barrier in the regulation of these sub­ stances will be discussed with special emphasis on the access through the blood-brain barrier to cardiovascular centers. 2 The Blood-Brain Barrier 2.

Keywords

Control Herz-Kreislauf-System Herz-Kreislauf-System /Erkrankung Nervous System Neuroendokrinologie

Editors and affiliations

  • Detlev Ganten
    • 1
  • Donald Pfaff
    • 2
  1. 1.Pharmakologisches InstitutUniversität HeidelbergHeidelbergGermany
  2. 2.Rockefeller UniversityNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68490-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68492-0
  • Online ISBN 978-3-642-68490-6
  • Series Print ISSN 0723-1229
  • Buy this book on publisher's site